Role of adapter function in oncoprotein-mediated activation of NF-κB: Human T-cell leukemia virus type I Tax interacts directly with IκB kinase γ

Dong Yan Jin, Vincenzo Giordano, Karen V. Kibler, Hiroyasu Nakano, Kuan Teh Jeang

Research output: Contribution to journalArticle

191 Scopus citations

Abstract

Mechanisms by which the human T-cell leukemia virus type I Tax oncoprotein activates NF-κB remain incompletely understood. Although others have described an interaction between Tax and a holo-IκB kinase (IKK) complex, the exact details of protein-protein contact are not fully defined. Here we show that Tax binds to neither IKK-α nor IKK-β but instead complexes directly with IKK-γ, a newly characterized component of the IKK complex. This direct interaction with IKK-γ correlates with Tax-induced IκB-α phosphorylation and NF-κB activation. Thus, our findings establish IKKγ as a key molecule for adapting an oncoprotein-specific signaling to IKK-α and IKK-β.

Original languageEnglish (US)
Pages (from-to)17402-17405
Number of pages4
JournalJournal of Biological Chemistry
Volume274
Issue number25
DOIs
StatePublished - Jun 18 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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