RNA precursor molecules and ribonucleases in E. coli

Sidney Altman, Hugh D. Robertson

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The post-transcriptional alteration of one E. coli RNA species (tyrosine tRNA) by nucleases is now understood in some detail. Knowledge of this pathway has allowed us to speculate on the nature and control of the processing of other E. coli RNA species by the combined attack of endo- and exo-nucleolytic ribonucleases. A review of the properties of known E. coli ribonucleases has led us consider which of these activities might be capable of functioning together in different pathways. The control of these nuclease activities (singly or in groups) may be exerted through structural transitions of RNA substrates or through ionic or protein cofactors.

Original languageEnglish (US)
Pages (from-to)83-93
Number of pages11
JournalMolecular and Cellular Biochemistry
Volume1
Issue number1
DOIs
StatePublished - Mar 1973
Externally publishedYes

Fingerprint

RNA Precursors
Ribonucleases
Escherichia coli
RNA
Molecules
Transfer RNA
Tyrosine
Substrates
Processing
ribonuclease E
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology
  • Medicine(all)

Cite this

RNA precursor molecules and ribonucleases in E. coli. / Altman, Sidney; Robertson, Hugh D.

In: Molecular and Cellular Biochemistry, Vol. 1, No. 1, 03.1973, p. 83-93.

Research output: Contribution to journalArticle

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