The study objective was to provide an approach to selecting routes to a proposed hazardous waste treatment and storage facility, based on a risk and vulnerability assessment. Probability estimates were based on national transportation accident rates for hazardous material carriers, local accident characteristics, and the magnitude of projected shipments to the facility. Release incident probabilities resulting from equipment failure in nonaccident situations were also considered. Population risk values were determined in order to compare each route segment. The vulnerability component evaluated the transportation risks against the capabilities of the area to respond to and mitigate the hazards.