Abstract
The use of phosphorimidazolidate intermediates for the conversion of ribonucleoside 5′-monophosphates to diphosphates and 5′-diphosphates to triphosphates is described and several examples are cited. The specific phosphorylation of ribonucleoside 5′-diphosphates to afford the linear rather than branched triphosphates is demonstrated. Also reported is the successful synthesis of the branched isomer of adenosine 5′-triphosphate, ψATP, the attempted preparation of which was first reported in 1949. Certain chemical and enzymatic properties of ψATP are described, as is the conversion of ψATP to ATP via a presumed cyclic meta-phosphate intermediate.
Original language | English (US) |
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Pages (from-to) | 4458-4463 |
Number of pages | 6 |
Journal | Biochemistry |
Volume | 12 |
Issue number | 22 |
DOIs | |
State | Published - Oct 1 1973 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry