Ribonuclease P

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

The gene coding for the RNA subunit of ribonuclease P (RNase P) is essential in all free-living organisms. TheRNAsubunit, itself, is an enzyme and, from its evolutionary tree,we can infer that it is a very ancient molecule. The specificity of this enzyme is that it cleaves other RNAmolecules at the junction of single-stranded and the 5' end of double-stranded regions of RNA. One can speculate that this molecule was very useful in an ancient world in cleaving long pieces of RNA, which must have contained hairpin regions in it, into shorter molecules with the capability of different functions from the longer parent. Today, the specificity of the enzyme can be used in designing drug therapies.

Original languageEnglish (US)
Pages (from-to)2936-2941
Number of pages6
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume366
Issue number1580
DOIs
StatePublished - Oct 27 2011
Externally publishedYes

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Ribonuclease P
ribonucleases
RNA
enzyme
Molecules
Enzymes
enzymes
Drug therapy
Double-Stranded RNA
drug therapy
drug
Genes
Drug Therapy
gene
organisms
genes

Keywords

  • Evolution
  • RNA enzyme
  • Substrate

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ribonuclease P. / Altman, Sidney.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 366, No. 1580, 27.10.2011, p. 2936-2941.

Research output: Contribution to journalReview article

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