Rhinovirus Inhibition by Bufadienolides1a)

Y. Kamano, George Pettit, H. Nakayoshi, G. R. Pettit, C. R. Smith

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

An evaluation of thirty-four bufadienolides and two related cardenolides against a series of rhinoviruses in vitro has been completed. Most of the bufadienolides were found to display some inhibitory activity. Scillarenin and 3-O-[N-(tert-butoxycarbonyl)hydrazido]succinylbufalin were found to be the most active with chemotherapeutic indices of 32 and 16, respectively. In general, the 14β-hydroxy-bufadienolides showed the strongest antiviral activity, and were found more toxic than the corresponding 14β,15β-epoxy-bufadienolides. Introduction of a 16β-hydroxy or 16β-acetoxy substituent into the 14β,15β-epoxybufadienolides enhanced their antiviral activity. Substituents at the 3β-, 5β-, and 19-positions appeared to affect only the level of toxicity.

Original languageEnglish (US)
Pages (from-to)326-332
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume36
Issue number1
DOIs
StatePublished - 1988

Keywords

  • Ch'an Su
  • antiviral
  • bufadienolide
  • rhinovirus

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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    Kamano, Y., Pettit, G., Nakayoshi, H., Pettit, G. R., & Smith, C. R. (1988). Rhinovirus Inhibition by Bufadienolides1a). Chemical and Pharmaceutical Bulletin, 36(1), 326-332. https://doi.org/10.1248/cpb.36.326