Abstract
An evaluation of thirty-four bufadienolides and two related cardenolides against a series of rhinoviruses in vitro has been completed. Most of the bufadienolides were found to display some inhibitory activity. Scillarenin and 3-O-[N-(tert-butoxycarbonyl)hydrazido]succinylbufalin were found to be the most active with chemotherapeutic indices of 32 and 16, respectively. In general, the 14β-hydroxy-bufadienolides showed the strongest antiviral activity, and were found more toxic than the corresponding 14β,15β-epoxy-bufadienolides. Introduction of a 16β-hydroxy or 16β-acetoxy substituent into the 14β,15β-epoxybufadienolides enhanced their antiviral activity. Substituents at the 3β-, 5β-, and 19-positions appeared to affect only the level of toxicity.
Original language | English (US) |
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Pages (from-to) | 326-332 |
Number of pages | 7 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 36 |
Issue number | 1 |
DOIs | |
State | Published - 1988 |
Keywords
- Ch'an Su
- antiviral
- bufadienolide
- rhinovirus
ASJC Scopus subject areas
- General Chemistry
- Drug Discovery