Revisiting glucose regulation in birds – A negative model of diabetes complications

Karen L. Sweazea

doi:10.1016/j.cbpb.2022.110778

Revisiting glucose regulation in birds – A negative model of diabetes complications

Karen L. Sweazea

Health Solutions, College of (CHS)

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Birds naturally have blood glucose concentrations that are nearly double levels measured for mammals of similar body size and studies have shown that birds are resistant to insulin-mediated glucose uptake into tissues. While a combination of high blood glucose and insulin resistance is associated with diabetes-related pathologies in mammals, birds do not develop such complications. Moreover, studies have shown that birds are resistant to oxidative stress and protein glycation and in fact, live longer than similar-sized mammals. This review seeks to explore how birds regulate blood glucose as well as various theories that might explain their apparent resistance to insulin-mediated glucose uptake and adaptations that enable them to thrive in a state of relative hyperglycemia.

Original language	English (US)
Article number	110778
Journal	Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology
Volume	262
DOIs	https://doi.org/10.1016/j.cbpb.2022.110778
State	Published - Oct 1 2022

Keywords

Avian
Bird
Diabetes
GLUT4
Glucose
Insulin
Insulin resistance
Oxidative stress
Review

ASJC Scopus subject areas

Biochemistry
Physiology
Aquatic Science
Animal Science and Zoology
Molecular Biology

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10.1016/j.cbpb.2022.110778

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abstract = "Birds naturally have blood glucose concentrations that are nearly double levels measured for mammals of similar body size and studies have shown that birds are resistant to insulin-mediated glucose uptake into tissues. While a combination of high blood glucose and insulin resistance is associated with diabetes-related pathologies in mammals, birds do not develop such complications. Moreover, studies have shown that birds are resistant to oxidative stress and protein glycation and in fact, live longer than similar-sized mammals. This review seeks to explore how birds regulate blood glucose as well as various theories that might explain their apparent resistance to insulin-mediated glucose uptake and adaptations that enable them to thrive in a state of relative hyperglycemia.",

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Revisiting glucose regulation in birds – A negative model of diabetes complications

Abstract

Keywords

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