Reversible switching between epigenetic states in honeybee behavioral subcastes

Brian R. Herb, Florian Wolschin, Kasper D. Hansen, Martin J. Aryee, Ben Langmead, Rafael Irizarry, Gro Amdam, Andrew P. Feinberg

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

In honeybee societies, distinct caste phenotypes are created from the same genotype, suggesting a role for epigenetics in deriving these behaviorally different phenotypes. We found no differences in DNA methylation between irreversible worker and queen castes, but substantial differences between nurses and forager subcastes. Reverting foragers back to nurses reestablished methylation levels for a majority of genes and provides, to the best of our knowledge, the first evidence in any organism of reversible epigenetic changes associated with behavior.

Original languageEnglish (US)
Pages (from-to)1371-1373
Number of pages3
JournalNature Neuroscience
Volume15
Issue number10
DOIs
StatePublished - Oct 2012

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Epigenomics
Social Class
Nurses
Phenotype
DNA Methylation
Methylation
Genotype
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Herb, B. R., Wolschin, F., Hansen, K. D., Aryee, M. J., Langmead, B., Irizarry, R., ... Feinberg, A. P. (2012). Reversible switching between epigenetic states in honeybee behavioral subcastes. Nature Neuroscience, 15(10), 1371-1373. https://doi.org/10.1038/nn.3218

Reversible switching between epigenetic states in honeybee behavioral subcastes. / Herb, Brian R.; Wolschin, Florian; Hansen, Kasper D.; Aryee, Martin J.; Langmead, Ben; Irizarry, Rafael; Amdam, Gro; Feinberg, Andrew P.

In: Nature Neuroscience, Vol. 15, No. 10, 10.2012, p. 1371-1373.

Research output: Contribution to journalArticle

Herb, BR, Wolschin, F, Hansen, KD, Aryee, MJ, Langmead, B, Irizarry, R, Amdam, G & Feinberg, AP 2012, 'Reversible switching between epigenetic states in honeybee behavioral subcastes', Nature Neuroscience, vol. 15, no. 10, pp. 1371-1373. https://doi.org/10.1038/nn.3218
Herb BR, Wolschin F, Hansen KD, Aryee MJ, Langmead B, Irizarry R et al. Reversible switching between epigenetic states in honeybee behavioral subcastes. Nature Neuroscience. 2012 Oct;15(10):1371-1373. https://doi.org/10.1038/nn.3218
Herb, Brian R. ; Wolschin, Florian ; Hansen, Kasper D. ; Aryee, Martin J. ; Langmead, Ben ; Irizarry, Rafael ; Amdam, Gro ; Feinberg, Andrew P. / Reversible switching between epigenetic states in honeybee behavioral subcastes. In: Nature Neuroscience. 2012 ; Vol. 15, No. 10. pp. 1371-1373.
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