Reversible folding-unfolding, aggregation protection, and multi-year stabilization, in high concentration protein solutions, using ionic liquids

Nolene Byrne; Li Min Wang; Jean Philippe Belieres; Charles Angell

doi:10.1039/b618943a

Reversible folding-unfolding, aggregation protection, and multi-year stabilization, in high concentration protein solutions, using ionic liquids

Nolene Byrne, Li Min Wang, Jean Philippe Belieres, Charles Angell

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

207 Scopus citations

Abstract

We report the reversible thermal unfolding/refolding, and long period stabilization against aggregation and hydrolysis, of >200 mg ml^-1 solutions of lysozyme in ionic liquid-rich, ice-avoiding, solvents.

Original language	English (US)
Pages (from-to)	2714-2716
Number of pages	3
Journal	Chemical Communications
Issue number	26
DOIs	https://doi.org/10.1039/b618943a
State	Published - 2007

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b618943a

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title = "Reversible folding-unfolding, aggregation protection, and multi-year stabilization, in high concentration protein solutions, using ionic liquids",

abstract = "We report the reversible thermal unfolding/refolding, and long period stabilization against aggregation and hydrolysis, of >200 mg ml-1 solutions of lysozyme in ionic liquid-rich, ice-avoiding, solvents.",

author = "Nolene Byrne and Wang, {Li Min} and Belieres, {Jean Philippe} and Charles Angell",

year = "2007",

doi = "10.1039/b618943a",

language = "English (US)",

pages = "2714--2716",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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T1 - Reversible folding-unfolding, aggregation protection, and multi-year stabilization, in high concentration protein solutions, using ionic liquids

AU - Byrne, Nolene

AU - Wang, Li Min

AU - Belieres, Jean Philippe

AU - Angell, Charles

PY - 2007

Y1 - 2007

N2 - We report the reversible thermal unfolding/refolding, and long period stabilization against aggregation and hydrolysis, of >200 mg ml-1 solutions of lysozyme in ionic liquid-rich, ice-avoiding, solvents.

AB - We report the reversible thermal unfolding/refolding, and long period stabilization against aggregation and hydrolysis, of >200 mg ml-1 solutions of lysozyme in ionic liquid-rich, ice-avoiding, solvents.

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U2 - 10.1039/b618943a

DO - 10.1039/b618943a

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JO - Chemical Communications

JF - Chemical Communications

IS - 26

ER -

Reversible folding-unfolding, aggregation protection, and multi-year stabilization, in high concentration protein solutions, using ionic liquids

Abstract

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