TY - JOUR
T1 - Reversible control of biomaterial properties for dynamically tuning cell behavior
AU - Fumasi, Fallon M.
AU - Stephanopoulos, Nicholas
AU - Holloway, Julianne L.
N1 - Funding Information:
The authors kindly acknowledge funding from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under Award Number R21AR074069, as well as Julio Bernal for creating the DNA schematics for Table.
Publisher Copyright:
© 2020 Wiley Periodicals, Inc.
PY - 2020/7/5
Y1 - 2020/7/5
N2 - In the past decade, significant advances in chemistry and manufacturing have enabled the development of increasingly complex and controllable biomaterials. A key innovation is the design of dynamic biomaterials that allow for user-specified, reversible, temporal control over material properties. In this review, we provide an overview of recent advancements in reversible biomaterials, including control of stiffness, chemistry, ligand presentation, and topography. These systems have wide-ranging applications within biomedical engineering, including in vitro disease models and tissue-engineered scaffolds to guide multistep biological processes.
AB - In the past decade, significant advances in chemistry and manufacturing have enabled the development of increasingly complex and controllable biomaterials. A key innovation is the design of dynamic biomaterials that allow for user-specified, reversible, temporal control over material properties. In this review, we provide an overview of recent advancements in reversible biomaterials, including control of stiffness, chemistry, ligand presentation, and topography. These systems have wide-ranging applications within biomedical engineering, including in vitro disease models and tissue-engineered scaffolds to guide multistep biological processes.
KW - bioengineering
KW - biomedical applications
KW - mechanical properties
UR - http://www.scopus.com/inward/record.url?scp=85079186268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079186268&partnerID=8YFLogxK
U2 - 10.1002/app.49058
DO - 10.1002/app.49058
M3 - Article
AN - SCOPUS:85079186268
SN - 0021-8995
VL - 137
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
IS - 25
M1 - 49058
ER -