Retinal Vessel Caliber and Lifelong Neuropsychological Functioning: Retinal Imaging as an Investigative Tool for Cognitive Epidemiology

Idan Shalev, Terrie E. Moffitt, Tien Y. Wong, Madeline Meier, Renate M. Houts, Jie Ding, Carol Y. Cheung, M. Kamran Ikram, Avshalom Caspi, Richie Poulton

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Why do more intelligent people live healthier and longer lives? One possibility is that intelligence tests assess health of the brain, but psychological science has lacked technology to evaluate this hypothesis. Digital retinal imaging, a new, noninvasive method to visualize microcirculation in the eye, may reflect vascular conditions in the brain. We studied the association between retinal vessel caliber and neuropsychological functioning in the representative Dunedin birth cohort. Wider venular caliber was associated with poorer neuropsychological functioning at midlife, independently of potentially confounding factors. This association was not limited to any specific test domain and extended to informants' reports of cohort members' cognitive difficulties in everyday life. Moreover, wider venular caliber was associated with lower childhood IQ tested 25 years earlier. The findings indicate that retinal venular caliber may be an indicator of neuropsychological health years before the onset of dementing diseases and suggest that digital retinal imaging may be a useful investigative tool for psychological science.

Original languageEnglish (US)
Pages (from-to)1198-1207
Number of pages10
JournalPsychological Science
Volume24
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Retinal Vessels
Epidemiology
Psychology
Intelligence Tests
Health
Brain
Microcirculation
Blood Vessels
Parturition
Technology
Johnny Depp
Vessel
Imaging
Psychological
Cohort

Keywords

  • brain
  • cognitive ability
  • cognitive neuroscience
  • intelligence
  • retinal imaging
  • venular caliber

ASJC Scopus subject areas

  • Psychology(all)
  • Arts and Humanities (miscellaneous)

Cite this

Retinal Vessel Caliber and Lifelong Neuropsychological Functioning : Retinal Imaging as an Investigative Tool for Cognitive Epidemiology. / Shalev, Idan; Moffitt, Terrie E.; Wong, Tien Y.; Meier, Madeline; Houts, Renate M.; Ding, Jie; Cheung, Carol Y.; Ikram, M. Kamran; Caspi, Avshalom; Poulton, Richie.

In: Psychological Science, Vol. 24, No. 7, 07.2013, p. 1198-1207.

Research output: Contribution to journalArticle

Shalev, I, Moffitt, TE, Wong, TY, Meier, M, Houts, RM, Ding, J, Cheung, CY, Ikram, MK, Caspi, A & Poulton, R 2013, 'Retinal Vessel Caliber and Lifelong Neuropsychological Functioning: Retinal Imaging as an Investigative Tool for Cognitive Epidemiology', Psychological Science, vol. 24, no. 7, pp. 1198-1207. https://doi.org/10.1177/0956797612470959
Shalev, Idan ; Moffitt, Terrie E. ; Wong, Tien Y. ; Meier, Madeline ; Houts, Renate M. ; Ding, Jie ; Cheung, Carol Y. ; Ikram, M. Kamran ; Caspi, Avshalom ; Poulton, Richie. / Retinal Vessel Caliber and Lifelong Neuropsychological Functioning : Retinal Imaging as an Investigative Tool for Cognitive Epidemiology. In: Psychological Science. 2013 ; Vol. 24, No. 7. pp. 1198-1207.
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