Rethinking vector immunology: The role of environmental temperature in shaping resistance

Courtney C. Murdock, Krijn P. Paaijmans, Diana Cox-Foster, Andrew F. Read, Matthew B. Thomas

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations


Recent ecological research has revealed that environmental factors can strongly affect insect immunity and influence the outcome of host-parasite interactions. To date, however, most studies examining immune function in mosquitoes have ignored environmental variability. We argue that one such environmental variable, temperature, influences both vector immunity and the parasite itself. As temperatures in the field can vary greatly from the ambient temperature in the laboratory, it will be essential to take temperature into account when studying vector immunology.

Original languageEnglish (US)
Pages (from-to)869-876
Number of pages8
JournalNature Reviews Microbiology
Issue number12
StatePublished - Dec 2012
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases


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