Results of positive cross-match transplantation in African American renal transplant recipients

P. West-Thielke, H. Herren, J. Thielke, J. Oberholzer, H. Sankary, V. Raofi, E. Benedetti, B. Kaplan

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations

    Abstract

    Positive cross-match (PXM) renal transplantation has been utilized to address the issue of the increasing demand for transplantation with the shortage of suitable organs. Our primary objective was to analyze the outcomes of African American (AA) PXM renal transplant recipients utilizing AA negative cross-match (NXM) renal transplant recipients as a comparator group. This was a retrospective study consisting of all PXM patients who underwent a desensitization protocol and all AA NXM transplant recipients at the University of Illinois at Chicago from July 2001 to March 2007. We found that AA PXM recipients had significantly lower estimated glomerular filtration rate (eGFR) at 1 year than AA NXM (46.2 vs. 60.6, p = 0.007). AA PXM who experienced acute rejection within the first year were more likely to have an eGFR less than 30 mL/min/1.73 m2 at 1 year compared to their NXM counterparts (45.5% vs. 12.5%, p = 0.034). Positive cross-match renal transplantation in AA seems to be associated with a high degree of AR and severe renal compromise at 1 year. Larger studies are needed to determine if protocols that are associated with good short-term outcomes in non-AA need to be modified for the AA population.

    Original languageEnglish (US)
    Pages (from-to)348-354
    Number of pages7
    JournalAmerican Journal of Transplantation
    Volume8
    Issue number2
    DOIs
    StatePublished - Feb 2008

    Keywords

    • African Americans
    • Graft survival
    • High risk
    • Outcomes
    • Positive cross-match
    • Renal transplant

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Transplantation
    • Pharmacology (medical)

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