Responses of terrestrial insects to hypoxia or hyperoxia

Jon Harrison, Melanie R. Frazier, Joanna R. Henry, Alexander Kaiser, C. J. Klok, Brenda Rascón

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

Oxygen is critically important for catabolic ATP generation but is also a dangerous source of reactive oxygen species. Insects respond to short-term exposure to hypoxia or hyperoxia with compensatory changes in spiracular opening and ventilation that reduce variation in internal PO2. Below critical PO2 values (Pc), nitric oxide and hypoxia inducible factor (HIF)-mediated pathways induce long-term responses such as compensatory tracheal growth, suppressed development, and acclimation of ventilation. Pc values are strongly affected by activity and ontogeny, due to changes in the ratio of tracheal conductance to metabolic rate. Although growth rates and development are suppressed by significant hypoxia in all species studied to date, adult body size is only affected in some species. Severe hyperoxia causes major oxidative stress and reduces survival, while moderate hyperoxia increases development times and body sizes in some species by unknown mechanisms.

Original languageEnglish (US)
Pages (from-to)4-17
Number of pages14
JournalRespiratory Physiology and Neurobiology
Volume154
Issue number1-2
DOIs
StatePublished - Nov 1 2006

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Keywords

  • Critical P
  • Hyperoxia
  • Hypoxia
  • Insects
  • Oxygen

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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