@article{cc6d2a4f480d410f9db5747488322860,
title = "Response heterogeneity to lifestyle intervention among Latino adolescents",
abstract = "Objective: To characterize the heterogeneity in response to lifestyle intervention among Latino adolescents with obesity. Methods: We conducted secondary data analysis of 90 Latino adolescents (age 15.4 ± 0.9 y, female 56.7%) with obesity (BMI% 98.1 ± 1.5%) that were enrolled in a 3 month lifestyle intervention and were followed for a year. Covariance pattern mixture models identified response phenotypes defined by changes in insulin sensitivity as measured using a 2 hour oral glucose tolerance test. Baseline characteristics were compared across response phenotypes using one-way ANOVA and chi-square test. Results: Three distinct response phenotypes (PH1, PH2, PH3) were identified. PH1 exhibited the most robust response defined by the greatest increase in insulin sensitivity over time (β ± SE, linear 0.52 ± 0.17, P <.001; quadratic −0.03 ± 0.01, P =.001). PH2 showed non-significant changes, while PH3 demonstrated modest short-term increases in insulin sensitivity which were not sustained over time (linear 0.08 ± 0.03, P =.002; quadratic −0.01 ± 0.002, P =.003). At baseline, PH3 (1.1 ± 0.4) was the most insulin resistant phenotype and exhibited the highest BMI% (98.5 ± 1.1%), 2 hours glucose concentrations (144.0 ± 27.5 mg/dL), and lowest beta-cell function as estimated by the oral disposition index (4.5 ± 2.8). Conclusion: Response to lifestyle intervention varies among Latino youth with obesity and suggests that precision approaches are warranted to meet the prevention needs of high risk youth.",
keywords = "diabetes prevention, insulin resistance, non-responder, precision medicine, responder",
author = "Armando Pe{\~n}a and Daniel McNeish and Ayers, {Stephanie L.} and Olson, {Micah L.} and {Vander Wyst}, {Kiley B.} and Williams, {Allison N.} and Shaibi, {Gabriel Q.}",
note = "Funding Information: We are grateful to all the research participants and families who devoted their time and energy to making this research possible. We would also like to thank Drs Joon Young Kim (Syracuse University) and Justin Ryder (University of Minnesota) for comments and critical feedback on the manuscript. This work was supported by grants from the National Institute on Minority Health and Health Disparities (P20MD002316 and U54MD002316) and the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK107579 and R01DK107579‐03S1). A portion of time preparing this manuscript was supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of Maternal Child Health Bureau Nutrition Training Grant, The TRANSCEND Program in Maternal Child Health Nutrition and Childhood Obesity Prevention (T79MC31884; PI: Bruening) and by an Institute for Educational Sciences (IES) statistical methodology grant (R305D190011; PI: McNeish). The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by HRSA, HHS, IES or the U.S. Government. Funding Information: We are grateful to all the research participants and families who devoted their time and energy to making this research possible. We would also like to thank Drs Joon Young Kim (Syracuse University) and Justin Ryder (University of Minnesota) for comments and critical feedback on the manuscript. This work was supported by grants from the National Institute on Minority Health and Health Disparities (P20MD002316 and U54MD002316) and the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK107579 and R01DK107579-03S1). A portion of time preparing this manuscript was supported by the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of Maternal Child Health Bureau Nutrition Training Grant, The TRANSCEND Program in Maternal Child Health Nutrition and Childhood Obesity Prevention (T79MC31884; PI: Bruening) and by an Institute for Educational Sciences (IES) statistical methodology grant (R305D190011; PI: McNeish). The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by HRSA, HHS, IES or the U.S. Government. Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2020",
month = dec,
day = "1",
doi = "10.1111/pedi.13120",
language = "English (US)",
volume = "21",
pages = "1430--1436",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Blackwell Munksgaard",
number = "8",
}