Resource Consumption, Sustainability, and Cancer

Irina Kareva, Benjamin Morin, Carlos Castillo-Chavez

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Preserving a system’s viability in the presence of diversity erosion is critical if the goal is to sustainably support biodiversity. Reduction in population heterogeneity, whether inter- or intraspecies, may increase population fragility, either decreasing its ability to adapt effectively to environmental changes or facilitating the survival and success of ordinarily rare phenotypes. The latter may result in over-representation of individuals who may participate in resource utilization patterns that can lead to over-exploitation, exhaustion, and, ultimately, collapse of both the resource and the population that depends on it. Here, we aim to identify regimes that can signal whether a consumer–resource system is capable of supporting viable degrees of heterogeneity. The framework used here is an expansion of a previously introduced consumer–resource type system of a population of individuals classified by their resource consumption. Application of the Reduction Theorem to the system enables us to evaluate the health of the system through tracking both the mean value of the parameter of resource (over)consumption, and the population variance, as both change over time. The article concludes with a discussion that highlights applicability of the proposed system to investigation of systems that are affected by particularly devastating overly adapted populations, namely cancerous cells. Potential intervention approaches for system management are discussed in the context of cancer therapies.

Original languageEnglish (US)
Pages (from-to)319-338
Number of pages20
JournalBulletin of Mathematical Biology
Volume77
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Sustainability
Sustainable development
cancer
Cancer
sustainability
neoplasms
Resources
Biodiversity
resource
Population
Erosion
Neoplasms
Health
phenotype
environmental change
viability
biodiversity
erosion
Population Characteristics
population growth

Keywords

  • Cancer
  • Evolution of resistance
  • Heterogeneity
  • Host-parasite
  • Resource-consumer
  • Sustainability

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Immunology
  • Mathematics(all)
  • Computational Theory and Mathematics
  • Neuroscience(all)
  • Pharmacology

Cite this

Resource Consumption, Sustainability, and Cancer. / Kareva, Irina; Morin, Benjamin; Castillo-Chavez, Carlos.

In: Bulletin of Mathematical Biology, Vol. 77, No. 2, 2014, p. 319-338.

Research output: Contribution to journalArticle

Kareva, Irina ; Morin, Benjamin ; Castillo-Chavez, Carlos. / Resource Consumption, Sustainability, and Cancer. In: Bulletin of Mathematical Biology. 2014 ; Vol. 77, No. 2. pp. 319-338.
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