Rescue of vaccinia virus lacking the E3L gene by mutants of E3L

H. W. Chang; L. H. Uribe; Bertram Jacobs

doi:10.1128/jvi.69.10.6605-6608.1995

Rescue of vaccinia virus lacking the E3L gene by mutants of E3L

H. W. Chang, L. H. Uribe, Bertram Jacobs

Life Sciences, School of (SOLS)

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108 Scopus citations

Abstract

Vaccinia virus with the E3L gene deleted was able to replicate in RK-13 but not HeLa cells. This host range phenotype could be complemented by an E3L gene expressed transiently from a plasmid. Analysis of mutants of E3L indicates that the ability to complement deletion of E3L correlates with the ability of mutated proteins to bind double-stranded RNA but not with their ability to migrate to the nucleus.

Original language	English (US)
Pages (from-to)	6605-6608
Number of pages	4
Journal	Journal of virology
Volume	69
Issue number	10
DOIs	https://doi.org/10.1128/jvi.69.10.6605-6608.1995
State	Published - Oct 1995

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.69.10.6605-6608.1995

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abstract = "Vaccinia virus with the E3L gene deleted was able to replicate in RK-13 but not HeLa cells. This host range phenotype could be complemented by an E3L gene expressed transiently from a plasmid. Analysis of mutants of E3L indicates that the ability to complement deletion of E3L correlates with the ability of mutated proteins to bind double-stranded RNA but not with their ability to migrate to the nucleus.",

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AU - Uribe, L. H.

AU - Jacobs, Bertram

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AB - Vaccinia virus with the E3L gene deleted was able to replicate in RK-13 but not HeLa cells. This host range phenotype could be complemented by an E3L gene expressed transiently from a plasmid. Analysis of mutants of E3L indicates that the ability to complement deletion of E3L correlates with the ability of mutated proteins to bind double-stranded RNA but not with their ability to migrate to the nucleus.

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Rescue of vaccinia virus lacking the E3L gene by mutants of E3L

Abstract

ASJC Scopus subject areas

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