Replicating an expanded genetic alphabet in cells

John C. Chaput

Research output: Contribution to journalArticle

4 Scopus citations


Recent advances in synthetic biology have made it possible to replicate an unnatural base pair in living cells. This study highlights the technologies developed to create a semisynthetic organism with an expanded genetic alphabet and the potential challenges of moving forward.

Original languageEnglish (US)
Pages (from-to)1869-1871
Number of pages3
JournalChembiochem : a European journal of chemical biology
Issue number13
Publication statusPublished - Sep 5 2014



  • expanded genetic alphabet
  • synthetic biology
  • unnatural base pairs
  • xenobiotic nucleic acid (XNA)

ASJC Scopus subject areas

  • Medicine(all)

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