Removal of basiliximab by plasmapheresis.

C. N. Okechukwu, H. U. Meier-Kriesche, D. Armstrong, D. Campbell, C. Gerbeau, B. Kaplan

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Basiliximab is a chimeric monoclonal antibody directed against the alpha chain of interleukin-2 (IL-2) receptors. Given its expected volume of distribution (plasma volume), therapeutic plasmapheresis may be expected to lower serum Basiliximab levels. A 20-mg dose of Basiliximab was given before plasmapheresis. Blood and pheresis fluid samples were obtained to monitor Basiliximab levels. A total of three blood samples were drawn: the first was obtained 4 hours before, the second sample immediately before commencement, and the third 2 hours after cessation of plasmapheresis. A fourth sample was obtained from the removed plasma. There was an appreciable reduction in Basiliximab concentration levels after plasmapheresis. From the change in serum concentration after plasmapheresis, approximately 64.6% of circulating Basiliximab was removed. Plasmapheresis removes substantial amounts of Basiliximab. Therefore, supplemental Basiliximab should be given after plasmapheresis to maintain the desired duration of IL-2R saturation.

Original languageEnglish (US)
Pages (from-to)E11
JournalAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
Volume37
Issue number1
StatePublished - Jan 2001

ASJC Scopus subject areas

  • Nephrology

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    Okechukwu, C. N., Meier-Kriesche, H. U., Armstrong, D., Campbell, D., Gerbeau, C., & Kaplan, B. (2001). Removal of basiliximab by plasmapheresis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 37(1), E11.