Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes

Daniel J. Cox, Boris P. Kovatchev, Linda A. Gonder-Frederick, Kent H. Summers, Anthony McCall, Kevin Grimm, William L. Clarke

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

OBJECTIVE - Hyperglycemia is a common event among patients with type 1 and type 2 diabetes. While the cognitive-motor slowing associated with hypoglycemia is well documented, the acute effects of hyperglycemia have not been studied extensively, despite patients' reports of negative effects. This study prospectively and objectively assessed the effects of hyperglycemia on cognitive-motor functioning in subjects' natural environment. RESEARCH DESIGN AND METHODS - Study 1 investigated 105 adults with type 1 diabetes (mean age 37 years and mean duration of diabetes 20 years), study 2 investigated 36 adults with type 2 diabetes (mean age 50 years and mean duration of diabetes 10 years), and study 3 investigated 91 adults with type 1 diabetes (mean age 39 years and mean duration of diabetes 20 years). Subjects used a hand-held computer for 70 trials over 4 weeks, which required them to complete various cognitive-motor tasks and then measure and enter their current blood glucose reading. RESULTS - Hyperglycemia (blood glucose >15 mmol/l) was associated with slowing of all cognitive performance tests (P < 0.02) and an increased number of mental subtraction errors for both type 1 and type 2 diabetic subjects. The effects of hyperglycemia were highly individualized, impacting ∼50% of the subjects. CONCLUSIONS - Acute hyperglycemia is not a benign event for many individuals with diabetes, but it is associated with mild cognitive dysfunction.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalDiabetes Care
Volume28
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

Type 1 Diabetes Mellitus
Hyperglycemia
Type 2 Diabetes Mellitus
Blood Glucose
Hypoglycemia
Reading
Research Design
Hand

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Cox, D. J., Kovatchev, B. P., Gonder-Frederick, L. A., Summers, K. H., McCall, A., Grimm, K., & Clarke, W. L. (2005). Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes. Diabetes Care, 28(1), 71-77. https://doi.org/10.2337/diacare.28.1.71

Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes. / Cox, Daniel J.; Kovatchev, Boris P.; Gonder-Frederick, Linda A.; Summers, Kent H.; McCall, Anthony; Grimm, Kevin; Clarke, William L.

In: Diabetes Care, Vol. 28, No. 1, 01.2005, p. 71-77.

Research output: Contribution to journalArticle

Cox, DJ, Kovatchev, BP, Gonder-Frederick, LA, Summers, KH, McCall, A, Grimm, K & Clarke, WL 2005, 'Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes', Diabetes Care, vol. 28, no. 1, pp. 71-77. https://doi.org/10.2337/diacare.28.1.71
Cox, Daniel J. ; Kovatchev, Boris P. ; Gonder-Frederick, Linda A. ; Summers, Kent H. ; McCall, Anthony ; Grimm, Kevin ; Clarke, William L. / Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes. In: Diabetes Care. 2005 ; Vol. 28, No. 1. pp. 71-77.
@article{fc45925dd95c423ba38cea0ffb204ed0,
title = "Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes",
abstract = "OBJECTIVE - Hyperglycemia is a common event among patients with type 1 and type 2 diabetes. While the cognitive-motor slowing associated with hypoglycemia is well documented, the acute effects of hyperglycemia have not been studied extensively, despite patients' reports of negative effects. This study prospectively and objectively assessed the effects of hyperglycemia on cognitive-motor functioning in subjects' natural environment. RESEARCH DESIGN AND METHODS - Study 1 investigated 105 adults with type 1 diabetes (mean age 37 years and mean duration of diabetes 20 years), study 2 investigated 36 adults with type 2 diabetes (mean age 50 years and mean duration of diabetes 10 years), and study 3 investigated 91 adults with type 1 diabetes (mean age 39 years and mean duration of diabetes 20 years). Subjects used a hand-held computer for 70 trials over 4 weeks, which required them to complete various cognitive-motor tasks and then measure and enter their current blood glucose reading. RESULTS - Hyperglycemia (blood glucose >15 mmol/l) was associated with slowing of all cognitive performance tests (P < 0.02) and an increased number of mental subtraction errors for both type 1 and type 2 diabetic subjects. The effects of hyperglycemia were highly individualized, impacting ∼50{\%} of the subjects. CONCLUSIONS - Acute hyperglycemia is not a benign event for many individuals with diabetes, but it is associated with mild cognitive dysfunction.",
author = "Cox, {Daniel J.} and Kovatchev, {Boris P.} and Gonder-Frederick, {Linda A.} and Summers, {Kent H.} and Anthony McCall and Kevin Grimm and Clarke, {William L.}",
year = "2005",
month = "1",
doi = "10.2337/diacare.28.1.71",
language = "English (US)",
volume = "28",
pages = "71--77",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "1",

}

TY - JOUR

T1 - Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes

AU - Cox, Daniel J.

AU - Kovatchev, Boris P.

AU - Gonder-Frederick, Linda A.

AU - Summers, Kent H.

AU - McCall, Anthony

AU - Grimm, Kevin

AU - Clarke, William L.

PY - 2005/1

Y1 - 2005/1

N2 - OBJECTIVE - Hyperglycemia is a common event among patients with type 1 and type 2 diabetes. While the cognitive-motor slowing associated with hypoglycemia is well documented, the acute effects of hyperglycemia have not been studied extensively, despite patients' reports of negative effects. This study prospectively and objectively assessed the effects of hyperglycemia on cognitive-motor functioning in subjects' natural environment. RESEARCH DESIGN AND METHODS - Study 1 investigated 105 adults with type 1 diabetes (mean age 37 years and mean duration of diabetes 20 years), study 2 investigated 36 adults with type 2 diabetes (mean age 50 years and mean duration of diabetes 10 years), and study 3 investigated 91 adults with type 1 diabetes (mean age 39 years and mean duration of diabetes 20 years). Subjects used a hand-held computer for 70 trials over 4 weeks, which required them to complete various cognitive-motor tasks and then measure and enter their current blood glucose reading. RESULTS - Hyperglycemia (blood glucose >15 mmol/l) was associated with slowing of all cognitive performance tests (P < 0.02) and an increased number of mental subtraction errors for both type 1 and type 2 diabetic subjects. The effects of hyperglycemia were highly individualized, impacting ∼50% of the subjects. CONCLUSIONS - Acute hyperglycemia is not a benign event for many individuals with diabetes, but it is associated with mild cognitive dysfunction.

AB - OBJECTIVE - Hyperglycemia is a common event among patients with type 1 and type 2 diabetes. While the cognitive-motor slowing associated with hypoglycemia is well documented, the acute effects of hyperglycemia have not been studied extensively, despite patients' reports of negative effects. This study prospectively and objectively assessed the effects of hyperglycemia on cognitive-motor functioning in subjects' natural environment. RESEARCH DESIGN AND METHODS - Study 1 investigated 105 adults with type 1 diabetes (mean age 37 years and mean duration of diabetes 20 years), study 2 investigated 36 adults with type 2 diabetes (mean age 50 years and mean duration of diabetes 10 years), and study 3 investigated 91 adults with type 1 diabetes (mean age 39 years and mean duration of diabetes 20 years). Subjects used a hand-held computer for 70 trials over 4 weeks, which required them to complete various cognitive-motor tasks and then measure and enter their current blood glucose reading. RESULTS - Hyperglycemia (blood glucose >15 mmol/l) was associated with slowing of all cognitive performance tests (P < 0.02) and an increased number of mental subtraction errors for both type 1 and type 2 diabetic subjects. The effects of hyperglycemia were highly individualized, impacting ∼50% of the subjects. CONCLUSIONS - Acute hyperglycemia is not a benign event for many individuals with diabetes, but it is associated with mild cognitive dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=11844306546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11844306546&partnerID=8YFLogxK

U2 - 10.2337/diacare.28.1.71

DO - 10.2337/diacare.28.1.71

M3 - Article

C2 - 15616236

AN - SCOPUS:11844306546

VL - 28

SP - 71

EP - 77

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 1

ER -