TY - JOUR
T1 - Relationships between hydration biomarkers and total fluid intake in pregnant and lactating women
AU - McKenzie, Amy L.
AU - Perrier, Erica T.
AU - Guelinckx, Isabelle
AU - Kavouras, Stavros A.
AU - Aerni, Giselle
AU - Lee, Elaine C.
AU - Volek, Jeff S.
AU - Maresh, Carl M.
AU - Armstrong, Lawrence E.
N1 - Funding Information:
The authors would like to thank the participants for their commitment to furthering scientific knowledge through their participation in this investigation and Lindsay Ellis for her technical assistance during data collection. Danone Research funded this investigation. I declare none on behalf of all authors.
Publisher Copyright:
© 2016, The Author(s).
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Introduction: Previous research established significant relationships between total fluid intake (TFI) and urinary biomarkers of the hydration process in free-living males and females; however, the nature of this relationship is not known for pregnant (PREG) and lactating (LACT) women. Purpose: To determine the relationship between urinary and hematological hydration biomarkers with TFI in PREG and LACT. Methods: Eighteen PREG/LACT (age: 31 ± 3 years, pre-pregnancy BMI: 24.26 ± 5.85 kg m−2) collected 24-h urine samples, recorded TFI, and provided a blood sample at 5 time points (15 ± 2, 26 ± 1, 37 ± 1 weeks gestation, 3 ± 1 and 9 ± 1 weeks postpartum during lactation); 18 pair-matched non-pregnant (NP), non-lactating (NL) women (age: 29 ± 4 years, BMI: 24.1 ± 3.7 kg m−2) provided samples at similar time intervals. Twenty-four-hour urine volume (UVOL), osmolality (UOSM), specific gravity (USG), and color (UCOL) were measured. Hematocrit, serum osmolality (SOSM), and serum total protein (STP) were measured in blood. Results: Significant relationships were present between TFI and urinary biomarkers in all women (P < 0.004); these relationships were not different between PREG and NP, and LACT and NL, except UVOL in PREG (P = 0.0017). No significant relationships between TFI and hematological biomarkers existed (P > 0.05). Conclusion: Urinary biomarkers of hydration, but not hematological biomarkers, have a strong relationship with TFI in PREG, LACT, NP, and NL women. These data suggest that urinary biomarkers of hydration reflect TFI during pregnancy and breast-feeding.
AB - Introduction: Previous research established significant relationships between total fluid intake (TFI) and urinary biomarkers of the hydration process in free-living males and females; however, the nature of this relationship is not known for pregnant (PREG) and lactating (LACT) women. Purpose: To determine the relationship between urinary and hematological hydration biomarkers with TFI in PREG and LACT. Methods: Eighteen PREG/LACT (age: 31 ± 3 years, pre-pregnancy BMI: 24.26 ± 5.85 kg m−2) collected 24-h urine samples, recorded TFI, and provided a blood sample at 5 time points (15 ± 2, 26 ± 1, 37 ± 1 weeks gestation, 3 ± 1 and 9 ± 1 weeks postpartum during lactation); 18 pair-matched non-pregnant (NP), non-lactating (NL) women (age: 29 ± 4 years, BMI: 24.1 ± 3.7 kg m−2) provided samples at similar time intervals. Twenty-four-hour urine volume (UVOL), osmolality (UOSM), specific gravity (USG), and color (UCOL) were measured. Hematocrit, serum osmolality (SOSM), and serum total protein (STP) were measured in blood. Results: Significant relationships were present between TFI and urinary biomarkers in all women (P < 0.004); these relationships were not different between PREG and NP, and LACT and NL, except UVOL in PREG (P = 0.0017). No significant relationships between TFI and hematological biomarkers existed (P > 0.05). Conclusion: Urinary biomarkers of hydration, but not hematological biomarkers, have a strong relationship with TFI in PREG, LACT, NP, and NL women. These data suggest that urinary biomarkers of hydration reflect TFI during pregnancy and breast-feeding.
KW - Blood biomarkers
KW - Breast-feeding
KW - Fluid intake adequacy
KW - Gestation
KW - Hydration status
KW - Urine biomarkers
UR - http://www.scopus.com/inward/record.url?scp=84982131041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982131041&partnerID=8YFLogxK
U2 - 10.1007/s00394-016-1256-3
DO - 10.1007/s00394-016-1256-3
M3 - Article
C2 - 27519184
AN - SCOPUS:84982131041
VL - 56
SP - 2161
EP - 2170
JO - Zeitschrift fur Ernahrungswissenschaft
JF - Zeitschrift fur Ernahrungswissenschaft
SN - 1436-6207
IS - 6
ER -