TY - JOUR
T1 - Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans
AU - Valiña-Tóth, Anna Liza B.
AU - Lai, Zongshan
AU - Yoo, Wonsuk
AU - Abou-Samra, Abdul
AU - Gadegbeku, Crystal A.
AU - Flack, John M.
PY - 2010/5
Y1 - 2010/5
N2 - Background Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known. Objective To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures. Design A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial. Measurements Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH ≤65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH. Results Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0·02), truncal (P = 0·03) and extremity (P = 0·03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0·02). Total fat mass in groups 1-3, respectively, was 30·0, 34·0 and 37·4 kg (P = 0·008); truncal fat mass was 13·4, 15·9 and 17·6 kg (P = 0·006) and extremity fat mass was 15·8, 16·9 and 19·7 kg (P = 0·02). Lean mass did not differ across the three groups. Conclusions Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.
AB - Background Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known. Objective To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures. Design A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial. Measurements Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH ≤65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH. Results Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0·02), truncal (P = 0·03) and extremity (P = 0·03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0·02). Total fat mass in groups 1-3, respectively, was 30·0, 34·0 and 37·4 kg (P = 0·008); truncal fat mass was 13·4, 15·9 and 17·6 kg (P = 0·006) and extremity fat mass was 15·8, 16·9 and 19·7 kg (P = 0·02). Lean mass did not differ across the three groups. Conclusions Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.
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U2 - 10.1111/j.1365-2265.2009.03676.x
DO - 10.1111/j.1365-2265.2009.03676.x
M3 - Article
C2 - 19656160
AN - SCOPUS:77950191587
SN - 0300-0664
VL - 72
SP - 595
EP - 603
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 5
ER -