@article{f473c082b7094dfc81f2b768ba5e09df,
title = "Relationship of Bugula neritina (Bryozoa) antineoplastic constituents to the yellow sponge Lissodendoryx isodictyalis",
abstract = "Lissodendoryx isodictyalis, a yellow marine animal of the Demospongiae class, was found to yield a series of closely related substances very active against the murine P388 lymphocytic leukemia. Separation studies guided by bioassay led to the isolation and characterization of the strongly antineoplastic (P388 leukemia) bryostatins 4–6 (la-c) and 8 (Id) accompanied by new bryostatins A and B. Yields of the bryostatins from 108 kg of wet Gulf of California L. isodictyalis ranged from 3.2 mg of bryostatin 4 to 900 μg and 700 μ g respectively of bryostatins A and B. The actual source of bryostatins 4–6 and 8 appeared to be from intrusion of the Bryozoan Bugula neritina. But bryostatins A (a deoxybryostatin 5) and B (a deoxybryostatin 4) have not hitherto been detected in B. neritina and may represent metabolic transformations performed by the sponge.",
author = "George Pettit and Yoshiaki Kamano and Herald, {Cherry L.} and Schmidt, {Jean M.} and Zubrodc, {C. Gordon}",
note = "Funding Information: thank Mary Dell Pritzlaff, the Olin Foundation (Spencer T. and Ann W.), the Fannie E. Rippel Foundation, Eleanor W. Libby, the Waddell Foundation (Donald Ware), the Flinn Foundation, the Robert B. Dalton Endowment Fund, the Upjohn Company, Virginia L. Bayless, Elias M. Romley, Contract NOl-CM-97262 with the Division of Cancer Treatment, NCI, NIH, DHHS and National Institutes of Health Grant No, CAl6049-0l.O9. Other very helpful assistance was provided by Drs. P. Brown, H. Cohen, C. M. Cragg, D. L. Doubek, P. D. Ellis, C. Hendler, L. W. Knapp, P. Lohavanijaya, M. I. Suffness, Mr. .1. F. Day, Miss S. A. O'Connor, Mr. C. F. Ochoa, Mrs. M. J. Pettit, Miss M. S. Pettit, Mr. L. D. Vanell, Mrs. K. Zubrod, the Smithsonian Institution Oceanographic Sorting Center and the National Science Foundation Regional Facility at the University of South Carolina (CH78-l8723).",
year = "1986",
month = jan,
day = "1",
doi = "10.1351/pac198658030415",
language = "English (US)",
volume = "58",
pages = "415--421",
journal = "Pure and Applied Chemistry",
issn = "0033-4545",
publisher = "IUPAC Secretariat",
number = "3",
}