Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron

Marco A. Herrera-Valdez, Erin C. McKiernan, Sandra D. Berger, Stefanie Ryglewski, Carsten Duch, Sharon Crook

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Neurons show diverse firing patterns. Even neurons belonging to a single chemical or morphological class, or the same identified neuron, can display different types of electrical activity. For example, motor neuron MN5, which innervates a flight muscle of adult Drosophila, can show distinct firing patterns under the same recording conditions. We developed a two-dimensional biophysical model and show that a core complement of just two voltage-gated channels is sufficient to generate firing pattern diversity. We propose Shab and DmNa v to be two candidate genes that could encode these core currents, and find that changes in Shab channel expression in the model can reproduce activity resembling the main firing patterns observed in MN5 recordings. We use bifurcation analysis to describe the different transitions between rest and spiking states that result from variations in Shab channel expression, exposing a connection between ion channel expression, bifurcation structure, and firing patterns in models of membrane potential dynamics.

Original languageEnglish (US)
Pages (from-to)211-229
Number of pages19
JournalJournal of Computational Neuroscience
Volume34
Issue number2
DOIs
StatePublished - Apr 2013

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Motor Neurons
Ion Channels
Neurons
Membrane Potentials
Drosophila
Muscles
Genes

Keywords

  • Bifurcation
  • Electrophysiology
  • Excitability
  • Firing pattern
  • Gene expression
  • Ion channels

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Sensory Systems

Cite this

Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. / Herrera-Valdez, Marco A.; McKiernan, Erin C.; Berger, Sandra D.; Ryglewski, Stefanie; Duch, Carsten; Crook, Sharon.

In: Journal of Computational Neuroscience, Vol. 34, No. 2, 04.2013, p. 211-229.

Research output: Contribution to journalArticle

Herrera-Valdez, Marco A. ; McKiernan, Erin C. ; Berger, Sandra D. ; Ryglewski, Stefanie ; Duch, Carsten ; Crook, Sharon. / Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. In: Journal of Computational Neuroscience. 2013 ; Vol. 34, No. 2. pp. 211-229.
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