Regulatory gene adaptation: An evolutionary model

Philip W. Hedrick; John F. McDonald

doi:10.1038/hdy.1980.52

Regulatory gene adaptation: An evolutionary model

Philip W. Hedrick, John F. McDonald

Life Sciences, School of (SOLS)

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

There is increasing support for the notion that changes in regulatory loci have played a major role in eukaryotic evolution. Assuming a model of genetic regulation based upon presently accepted views of the organisation of the eukaryotic genome and basic models of evolutionary genetics, one can provide a context for speculation about the advantages and disadvantages of adaptation via regulatory genes. As additional information is obtained on particular regulatory systems, the evolutionary genetic model can be modified and expanded.

Original language	English (US)
Pages (from-to)	83-97
Number of pages	15
Journal	Heredity
Volume	45
Issue number	1
DOIs	https://doi.org/10.1038/hdy.1980.52
State	Published - Aug 1980

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Access to Document

10.1038/hdy.1980.52

Cite this

@article{7af320d3ff584dd294689c457a57cba1,

title = "Regulatory gene adaptation: An evolutionary model",

abstract = "There is increasing support for the notion that changes in regulatory loci have played a major role in eukaryotic evolution. Assuming a model of genetic regulation based upon presently accepted views of the organisation of the eukaryotic genome and basic models of evolutionary genetics, one can provide a context for speculation about the advantages and disadvantages of adaptation via regulatory genes. As additional information is obtained on particular regulatory systems, the evolutionary genetic model can be modified and expanded.",

author = "Hedrick, {Philip W.} and McDonald, {John F.}",

note = "Funding Information: Acknowledgements.—We are grateful for comments by James Crow, John Grula, Richard Lewontin, Ross Maclntyre, Jeff Mitton, Elizabeth Murray, Martin Tracy, and Alan Wilson and for the discussion following our paper at the Evolution meeting in 1978. This work was in part supported by NSF Grant DEB-78 15466 to J.M.",

year = "1980",

month = aug,

doi = "10.1038/hdy.1980.52",

language = "English (US)",

volume = "45",

pages = "83--97",

journal = "Heredity",

issn = "0018-067X",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Regulatory gene adaptation

T2 - An evolutionary model

AU - Hedrick, Philip W.

AU - McDonald, John F.

N1 - Funding Information: Acknowledgements.—We are grateful for comments by James Crow, John Grula, Richard Lewontin, Ross Maclntyre, Jeff Mitton, Elizabeth Murray, Martin Tracy, and Alan Wilson and for the discussion following our paper at the Evolution meeting in 1978. This work was in part supported by NSF Grant DEB-78 15466 to J.M.

PY - 1980/8

Y1 - 1980/8

N2 - There is increasing support for the notion that changes in regulatory loci have played a major role in eukaryotic evolution. Assuming a model of genetic regulation based upon presently accepted views of the organisation of the eukaryotic genome and basic models of evolutionary genetics, one can provide a context for speculation about the advantages and disadvantages of adaptation via regulatory genes. As additional information is obtained on particular regulatory systems, the evolutionary genetic model can be modified and expanded.

AB - There is increasing support for the notion that changes in regulatory loci have played a major role in eukaryotic evolution. Assuming a model of genetic regulation based upon presently accepted views of the organisation of the eukaryotic genome and basic models of evolutionary genetics, one can provide a context for speculation about the advantages and disadvantages of adaptation via regulatory genes. As additional information is obtained on particular regulatory systems, the evolutionary genetic model can be modified and expanded.

UR - http://www.scopus.com/inward/record.url?scp=0019050828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019050828&partnerID=8YFLogxK

U2 - 10.1038/hdy.1980.52

DO - 10.1038/hdy.1980.52

M3 - Article

C2 - 7440246

AN - SCOPUS:0019050828

SN - 0018-067X

VL - 45

SP - 83

EP - 97

JO - Heredity

JF - Heredity

IS - 1

ER -

Regulatory gene adaptation: An evolutionary model

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this