Regulatory factors of induced pluripotency: Current status

Wei Zhao, Bo Ning, Chen Qian

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) through enforced expression of four transcription factors [Oct4, Sox2, Klf4, and c-Myc (OSKM)]; however, the reprogramming efficiency is extremely low. This finding raises fundamental questions about the regulators that influence the change in epigenetic stability and endowment of dedifferentiation potential during reprogramming. Identification of such regulators is critical to removing the roadblocks impeding the efficient generation of safe iPSCs and their successful translation into clinical therapies. In this review, we summarize the current progress that has been made in understanding cellular reprogramming, with an emphasis on the molecular mechanisms of epigenetic regulators in induced pluripotency.

Original languageEnglish (US)
Article number15
JournalStem Cell Investigation
Volume2014
Issue numberJUL
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Cellular reprogramming
  • Epigenetic reprogramming
  • Epigenetics
  • Induced pluripotent stem cells (iPSCs)

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology
  • Cell Biology

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