Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads

Sirio Dupont, Masafumi Inui, Stuart Newfeld

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Polyubiquitylation leading to proteasomal degradation is a well-established mechanism for regulating TGF-β signal transduction components such as receptors and Smads. Recently, an equally important role was suggested for monoubiquitylation of both Smad4 and receptor-associated Smads that regulates their function without protein degradation. Monoubiquitylation of Smads was discovered following the identification of deubiquitylases required for TGF-β signaling, suggesting that continuous cycles of Smad mono- and deubiquitylation are required for proper TGF-β signal transduction. Here we summarize and discuss recent work on Smad mono- and deubiquitylation.

Original languageEnglish (US)
Pages (from-to)1913-1920
Number of pages8
JournalFEBS Letters
Volume586
Issue number14
DOIs
StatePublished - Jul 4 2012

Fingerprint

Signal transduction
Signal Transduction
Degradation
Proteolysis
Proteins

Keywords

  • BMP
  • Ectodermin/Tif1-γ/Trim33
  • Fat facets/Fam/Usp9X
  • Smad4/Medea
  • Usp15

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads. / Dupont, Sirio; Inui, Masafumi; Newfeld, Stuart.

In: FEBS Letters, Vol. 586, No. 14, 04.07.2012, p. 1913-1920.

Research output: Contribution to journalArticle

Dupont, Sirio ; Inui, Masafumi ; Newfeld, Stuart. / Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads. In: FEBS Letters. 2012 ; Vol. 586, No. 14. pp. 1913-1920.
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