Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals

Karen L. Denzler, Robert Waters, Bertram Jacobs, Yvan Rochon, Jeffrey Langland

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. While there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy of these botanicals, limited scientific evidence exists on the ability of these botanicals to modulate the immune and inflammatory responses. Using botanogenomics (or herbogenomics), this study provides novel insight into inflammatory genes which are induced in peripheral blood mononuclear cells following treatment with immunomodulatory botanical extracts. These results may suggest putative genes involved in the physiological responses thought to occur following administration of these botanical extracts. Using extracts from immunostimulatory herbs (Astragalus membranaceus, Sambucus cerulea, Andrographis paniculata) and an immunosuppressive herb (Urtica dioica), the data presented supports previous cytokine studies on these herbs as well as identifying additional genes which may be involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation. Additionally, we report the presence of lipopolysaccharide in medicinally prepared extracts of these herbs which is theorized to be a natural and active component of the immunostimulatory herbal extracts. The data presented provides a more extensive picture on how these herbs may be mediating their biological effects on the immune and inflammatory responses. & copy; 2010 Denzler et al.

Original languageEnglish (US)
Article numbere12561
Pages (from-to)1-15
Number of pages15
JournalPLoS One
Volume5
Issue number9
DOIs
StatePublished - 2010

Fingerprint

Gene Expression Regulation
mononuclear leukocytes
Gene expression
herbs
Genes
Complementary Therapies
gene expression
extracts
Sambucus
Astragalus membranaceus
Urtica dioica
Andrographis
alternative medicine
inflammation
Sambucus cerulea
Blood pressure
Therapeutic Uses
Immunosuppressive Agents
Wound Healing
Medicine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals. / Denzler, Karen L.; Waters, Robert; Jacobs, Bertram; Rochon, Yvan; Langland, Jeffrey.

In: PLoS One, Vol. 5, No. 9, e12561, 2010, p. 1-15.

Research output: Contribution to journalArticle

Denzler, Karen L. ; Waters, Robert ; Jacobs, Bertram ; Rochon, Yvan ; Langland, Jeffrey. / Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals. In: PLoS One. 2010 ; Vol. 5, No. 9. pp. 1-15.
@article{9b48f094345c4500b67563122e684db8,
title = "Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals",
abstract = "Many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. While there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy of these botanicals, limited scientific evidence exists on the ability of these botanicals to modulate the immune and inflammatory responses. Using botanogenomics (or herbogenomics), this study provides novel insight into inflammatory genes which are induced in peripheral blood mononuclear cells following treatment with immunomodulatory botanical extracts. These results may suggest putative genes involved in the physiological responses thought to occur following administration of these botanical extracts. Using extracts from immunostimulatory herbs (Astragalus membranaceus, Sambucus cerulea, Andrographis paniculata) and an immunosuppressive herb (Urtica dioica), the data presented supports previous cytokine studies on these herbs as well as identifying additional genes which may be involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation. Additionally, we report the presence of lipopolysaccharide in medicinally prepared extracts of these herbs which is theorized to be a natural and active component of the immunostimulatory herbal extracts. The data presented provides a more extensive picture on how these herbs may be mediating their biological effects on the immune and inflammatory responses. & copy; 2010 Denzler et al.",
author = "Denzler, {Karen L.} and Robert Waters and Bertram Jacobs and Yvan Rochon and Jeffrey Langland",
year = "2010",
doi = "10.1371/journal.pone.0012561",
language = "English (US)",
volume = "5",
pages = "1--15",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

TY - JOUR

T1 - Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals

AU - Denzler, Karen L.

AU - Waters, Robert

AU - Jacobs, Bertram

AU - Rochon, Yvan

AU - Langland, Jeffrey

PY - 2010

Y1 - 2010

N2 - Many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. While there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy of these botanicals, limited scientific evidence exists on the ability of these botanicals to modulate the immune and inflammatory responses. Using botanogenomics (or herbogenomics), this study provides novel insight into inflammatory genes which are induced in peripheral blood mononuclear cells following treatment with immunomodulatory botanical extracts. These results may suggest putative genes involved in the physiological responses thought to occur following administration of these botanical extracts. Using extracts from immunostimulatory herbs (Astragalus membranaceus, Sambucus cerulea, Andrographis paniculata) and an immunosuppressive herb (Urtica dioica), the data presented supports previous cytokine studies on these herbs as well as identifying additional genes which may be involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation. Additionally, we report the presence of lipopolysaccharide in medicinally prepared extracts of these herbs which is theorized to be a natural and active component of the immunostimulatory herbal extracts. The data presented provides a more extensive picture on how these herbs may be mediating their biological effects on the immune and inflammatory responses. & copy; 2010 Denzler et al.

AB - Many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. While there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy of these botanicals, limited scientific evidence exists on the ability of these botanicals to modulate the immune and inflammatory responses. Using botanogenomics (or herbogenomics), this study provides novel insight into inflammatory genes which are induced in peripheral blood mononuclear cells following treatment with immunomodulatory botanical extracts. These results may suggest putative genes involved in the physiological responses thought to occur following administration of these botanical extracts. Using extracts from immunostimulatory herbs (Astragalus membranaceus, Sambucus cerulea, Andrographis paniculata) and an immunosuppressive herb (Urtica dioica), the data presented supports previous cytokine studies on these herbs as well as identifying additional genes which may be involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation. Additionally, we report the presence of lipopolysaccharide in medicinally prepared extracts of these herbs which is theorized to be a natural and active component of the immunostimulatory herbal extracts. The data presented provides a more extensive picture on how these herbs may be mediating their biological effects on the immune and inflammatory responses. & copy; 2010 Denzler et al.

UR - http://www.scopus.com/inward/record.url?scp=77958548066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958548066&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0012561

DO - 10.1371/journal.pone.0012561

M3 - Article

VL - 5

SP - 1

EP - 15

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 9

M1 - e12561

ER -