Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals.

Karen L. Denzler, Robert Waters, Bertram L. Jacobs, Yvan Rochon, Jeffrey O. Langland

Research output: Contribution to journalArticle

Abstract

Many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. While there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy of these botanicals, limited scientific evidence exists on the ability of these botanicals to modulate the immune and inflammatory responses. Using botanogenomics (or herbogenomics), this study provides novel insight into inflammatory genes which are induced in peripheral blood mononuclear cells following treatment with immunomodulatory botanical extracts. These results may suggest putative genes involved in the physiological responses thought to occur following administration of these botanical extracts. Using extracts from immunostimulatory herbs (Astragalus membranaceus, Sambucus cerulea, Andrographis paniculata) and an immunosuppressive herb (Urtica dioica), the data presented supports previous cytokine studies on these herbs as well as identifying additional genes which may be involved in immune cell activation and migration and various inflammatory responses, including wound healing, angiogenesis, and blood pressure modulation. Additionally, we report the presence of lipopolysaccharide in medicinally prepared extracts of these herbs which is theorized to be a natural and active component of the immunostimulatory herbal extracts. The data presented provides a more extensive picture on how these herbs may be mediating their biological effects on the immune and inflammatory responses.

Original languageEnglish (US)
Article numbere12561
JournalPLoS One
Volume5
Issue number9
StatePublished - 2010
Externally publishedYes

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Gene Expression Regulation
mononuclear leukocytes
Gene expression
herbs
Genes
Complementary Therapies
gene expression
extracts
Sambucus
Astragalus membranaceus
Urtica dioica
Andrographis
alternative medicine
inflammation
Sambucus cerulea
Blood pressure
Therapeutic Uses
Immunosuppressive Agents
Wound Healing
Medicine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Denzler, K. L., Waters, R., Jacobs, B. L., Rochon, Y., & Langland, J. O. (2010). Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals. PLoS One, 5(9), [e12561].

Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals. / Denzler, Karen L.; Waters, Robert; Jacobs, Bertram L.; Rochon, Yvan; Langland, Jeffrey O.

In: PLoS One, Vol. 5, No. 9, e12561, 2010.

Research output: Contribution to journalArticle

Denzler, KL, Waters, R, Jacobs, BL, Rochon, Y & Langland, JO 2010, 'Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals.', PLoS One, vol. 5, no. 9, e12561.
Denzler, Karen L. ; Waters, Robert ; Jacobs, Bertram L. ; Rochon, Yvan ; Langland, Jeffrey O. / Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals. In: PLoS One. 2010 ; Vol. 5, No. 9.
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