Regulation of cyclo-oxygenase-2

Elizabeth Stack, Raymond N. DuBois

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Over the past three decades studies have been conducted to determine the role of prostaglandins in normal physiology and in certain diseases. Cyclo-oxygenase (COX) or prostaglandin endoperoxide synthase (Pghs) is required for the conversion of arachidonic acid to prostaglandins. Two isoforms of this enzyme have been identified which are referred to as COX-1 and COX-2. Under most circumstances, COX-1 is produced constitutively, whereas COX-2 can be induced by several physiological stimuli and is expressed at sites of inflammation. Although these isozymes catalyze identical reactions, they are often regulated by different signalling systems. The goal of this chapter is to provide a review of the role of cyclo-oxygenase in biology and disease, and to summarize the current understanding of mechanisms for the regulation of COX-2 expression.

Original languageEnglish (US)
Pages (from-to)787-800
Number of pages14
JournalBest Practice and Research: Clinical Gastroenterology
Volume15
Issue number5
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Arachidonic acid
  • Cyclo-oxygenase
  • Eicosanoids
  • Prostaglandins

ASJC Scopus subject areas

  • Gastroenterology

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