Regulation of cyclo-oxygenase-2

Elizabeth Stack, Raymond N. DuBois

    Research output: Contribution to journalArticlepeer-review

    18 Scopus citations

    Abstract

    Over the past three decades studies have been conducted to determine the role of prostaglandins in normal physiology and in certain diseases. Cyclo-oxygenase (COX) or prostaglandin endoperoxide synthase (Pghs) is required for the conversion of arachidonic acid to prostaglandins. Two isoforms of this enzyme have been identified which are referred to as COX-1 and COX-2. Under most circumstances, COX-1 is produced constitutively, whereas COX-2 can be induced by several physiological stimuli and is expressed at sites of inflammation. Although these isozymes catalyze identical reactions, they are often regulated by different signalling systems. The goal of this chapter is to provide a review of the role of cyclo-oxygenase in biology and disease, and to summarize the current understanding of mechanisms for the regulation of COX-2 expression.

    Original languageEnglish (US)
    Pages (from-to)787-800
    Number of pages14
    JournalBest Practice and Research: Clinical Gastroenterology
    Volume15
    Issue number5
    DOIs
    StatePublished - 2001

    Keywords

    • Arachidonic acid
    • Cyclo-oxygenase
    • Eicosanoids
    • Prostaglandins

    ASJC Scopus subject areas

    • Gastroenterology

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