Regional neuronal loss in aging and alzheimer’s disease: A brief review

M. Kerry O’Banion; Paul D. Coleman; Linda M. Callahan

doi:10.1006/smns.1994.1039

Regional neuronal loss in aging and alzheimer’s disease: A brief review

M. Kerry O’Banion, Paul D. Coleman, Linda M. Callahan

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

It is widely recognized that regional neuronal loss occurs during normal aging and that excessive neuronal loss in specific regions is one hallmark of Alzheimer’s disease (AD). Modern counting techniques have started to better define the degree of neuronal loss in aging and AD. Although there is some overlap with regions affected during aging, it is clear that Alzheimer’s disease represents a specific entity. By determining the regions and types of neurons that are vulnerable we can hope to better understand the causes and processes of normal aging and Alzheimer’s disease, as well as develop potential therapies.

Original language	English (US)
Pages (from-to)	307-314
Number of pages	8
Journal	Seminars in the Neurosciences
Volume	6
Issue number	5
DOIs	https://doi.org/10.1006/smns.1994.1039
State	Published - 1994
Externally published	Yes

Keywords

Amygdala
Cerebral cortex
Counting methods
Hippocampus
Subcortical nuclei

ASJC Scopus subject areas

General Neuroscience

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10.1006/smns.1994.1039

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abstract = "It is widely recognized that regional neuronal loss occurs during normal aging and that excessive neuronal loss in specific regions is one hallmark of Alzheimer{\textquoteright}s disease (AD). Modern counting techniques have started to better define the degree of neuronal loss in aging and AD. Although there is some overlap with regions affected during aging, it is clear that Alzheimer{\textquoteright}s disease represents a specific entity. By determining the regions and types of neurons that are vulnerable we can hope to better understand the causes and processes of normal aging and Alzheimer{\textquoteright}s disease, as well as develop potential therapies.",

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AB - It is widely recognized that regional neuronal loss occurs during normal aging and that excessive neuronal loss in specific regions is one hallmark of Alzheimer’s disease (AD). Modern counting techniques have started to better define the degree of neuronal loss in aging and AD. Although there is some overlap with regions affected during aging, it is clear that Alzheimer’s disease represents a specific entity. By determining the regions and types of neurons that are vulnerable we can hope to better understand the causes and processes of normal aging and Alzheimer’s disease, as well as develop potential therapies.

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KW - Cerebral cortex

KW - Counting methods

KW - Hippocampus

KW - Subcortical nuclei

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Regional neuronal loss in aging and alzheimer’s disease: A brief review

Abstract

Keywords

ASJC Scopus subject areas

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