Regional localization of over 300 loci on human chromosome 22 using a somatic cell hybrid mapping panel

Marcia L. Budarf, Barbara Eckman, Dominique Michaud, Terrence McDonald, Stacey Gavigan, Kenneth H. Buetow, Yvonne Tatsumura, Zonglu Liu, Catherine Hilliard, Deborah Driscoll, Elizabeth Goldmuntz, Eckart Meese, Ellen C. Zwarthoff, Sloan Williams, Heather McDermid, Jan P. Dumanski, Jaclyn Biegel, Callum J. Bell, Beverly S. Emanuel

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A somatic cell hybrid panel, consisting of 25 cell lines, has been developed to localize loci subregionally on chromosome 22. Over 300 markers in the form of STSs or hybridization probes have been assigned to one of 24 unique regions or 'bins' using this panel. This ordered collection of markers will aid in the assembly of physical maps and contigs of chromosome 22 and assist in positional cloning of disease loci mapped to chromosome 22.

Original languageEnglish (US)
Pages (from-to)275-288
Number of pages14
JournalGenomics
Volume35
Issue number2
DOIs
StatePublished - Jul 15 1996
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Budarf, M. L., Eckman, B., Michaud, D., McDonald, T., Gavigan, S., Buetow, K. H., Tatsumura, Y., Liu, Z., Hilliard, C., Driscoll, D., Goldmuntz, E., Meese, E., Zwarthoff, E. C., Williams, S., McDermid, H., Dumanski, J. P., Biegel, J., Bell, C. J., & Emanuel, B. S. (1996). Regional localization of over 300 loci on human chromosome 22 using a somatic cell hybrid mapping panel. Genomics, 35(2), 275-288. https://doi.org/10.1006/geno.1996.0358