Reduction in TrkA-immunoreactive neurons is not associated with an overexpression of galaninergic fibers within the nucleus basalis in Down's syndrome

T. J. Sendera, S. Y. Ma, S. Jaffar, P. B. Kozlowski, J. H. Kordower, Y. Mawal, H. U. Saragovi, E. J. Mufson

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Down's syndrome (DS) individuals develop neuropathological features similar to Alzheimer's disease (AD), including degeneration of cholinergic basal forebrain (CBF) neurons. In AD a reduction in CBF/trkA-containing neurons has been suggested to trigger a hyperexpression of galaninergic fibers within the nucleus basalis subfield of the basal forebrain. The present study examined the interrelationship between reductions in CBF/trkA- containing neurons and the overexpression of galaninergic fibers within the nucleus basalis in DS. Within the nucleus basalis stereologic evaluation revealed a 46% reduction in the number of trkA-immunopositive neurons, whereas optical density measurements d splayed a nonsignificant 18% reduction in neuronal trkA immunoreactivity in DS as compared with age-matched controls. Western blot analysis also showed a significant reduction in cortical trkA protein levels in DS. A semiquantitative examination of galaninergic fibers in the nucleus basalis revealed only a modest hypertrophy of galaninergic fibers within the nucleus basalis in DS. The present findings indicate a significant reduction in trkA within the nucleus basalis and cortex with only a moderate hypertrophy of galaninergic fibers in DS. These observations suggest that DS may not be an exact genetic model for investigation of changes in the AD basal forebrain.

Original languageEnglish (US)
Pages (from-to)1185-1196
Number of pages12
JournalJournal of Neurochemistry
Volume74
Issue number3
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Cholinergic basal forebrain neurons
  • Down's syndrome
  • Galaninergic fibers
  • Nucleus basalis
  • TrkA-immunoreactive neurons

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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