Reduced Repertoire of Cortical Microstates and Neuronal Ensembles in Medically Induced Loss of Consciousness

Michael Wenzel, Shuting Han, Elliot H. Smith, Erik Hoel, Bradley Greger, Paul A. House, Rafael Yuste

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Medically induced loss of consciousness (mLOC)during anesthesia is associated with a macroscale breakdown of brain connectivity, yet the neural microcircuit correlates of mLOC remain unknown. To explore this, we applied different analytical approaches (t-SNE/watershed segmentation, affinity propagation clustering, PCA, and LZW complexity)to two-photon calcium imaging of neocortical and hippocampal microcircuit activity and local field potential (LFP)measurements across different anesthetic depths in mice, and to micro-electrode array recordings in human subjects. We find that in both cases, mLOC disrupts population activity patterns by generating (1)fewer discriminable network microstates and (2)fewer neuronal ensembles. Our results indicate that local neuronal ensemble dynamics could causally contribute to the emergence of conscious states.

Original languageEnglish (US)
Pages (from-to)467-474.e4
JournalCell Systems
Volume8
Issue number5
DOIs
StatePublished - May 22 2019

Fingerprint

Unconsciousness
Passive Cutaneous Anaphylaxis
Photons
Cluster Analysis
Anesthetics
Electrodes
Anesthesia
Calcium
Brain
Population

Keywords

  • Calcium imaging
  • Coma
  • Consciousness
  • Ensembles
  • Information theory
  • Local networks
  • Microelectrode array
  • Microscale

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Reduced Repertoire of Cortical Microstates and Neuronal Ensembles in Medically Induced Loss of Consciousness. / Wenzel, Michael; Han, Shuting; Smith, Elliot H.; Hoel, Erik; Greger, Bradley; House, Paul A.; Yuste, Rafael.

In: Cell Systems, Vol. 8, No. 5, 22.05.2019, p. 467-474.e4.

Research output: Contribution to journalArticle

Wenzel, Michael ; Han, Shuting ; Smith, Elliot H. ; Hoel, Erik ; Greger, Bradley ; House, Paul A. ; Yuste, Rafael. / Reduced Repertoire of Cortical Microstates and Neuronal Ensembles in Medically Induced Loss of Consciousness. In: Cell Systems. 2019 ; Vol. 8, No. 5. pp. 467-474.e4.
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