Chickens of line 7, highly susceptible to Marek's disease (MD), were depleted of T cells by neonatal thymectomy, total body γ irradiation, and multiple injections with antithymocyte serum. In two replicate experiments, significantly fewer gross lymphomas were present in T cell depleted chickens than in intact or in T cell depleted, reconstituted hatchmates; these findings provided evidence that T cells may be the principal target for MD virus (MDV) transformation. T cell depletion was not complete, and the presence of microscopic lesions in T cell depleted chickens was attributed to residual T cells. Ten lymphomas from intact chickens and 2 lymphomas from a T cell depleted chicken were examined for cellular composition. All lymphomas consisted predominantly of T cells. The results of this and other published studies indicated that T cells may have a dual role in MD: they may serve as a target for lymphoma formation by MDV and also may participate in immune serveillance against the disease in resistant chickens.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of the National Cancer Institute|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Cancer Research