Reduced efficacy of hemorrhagic enteritis virus vaccine in turkeys exposed to avian pneumovirus

Parag Chary, Silke Rautenschlein, Jagdev M. Sharma

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Avian pneumovirus (APV) is an immunosuppressive respiratory pathogen of turkeys. We examined the effect of APV infection on the vaccine efficacy of hemorrhagic enteritis virus (HEV) vaccines. APV was inoculated in 2-wk-old turkeys. Two or four days later, an attenuated HEV vaccine (HEVp30) or marble spleen disease virus (MSDV) vaccine were administered. Virulent HEV challenge was given 19 days after HEV vaccination. APV exposure compromised the ability of HEVp30 and MSDV to protect turkeys against virulent HEV. The protective index values were as follows: MSDV (100%) versus APV + MSDV (0%) (P < 0.05); HEVp30 (60%) versus APV + HEVp30 (30%) (P < 0.05) (Experiment I) and HEVp30 (56%) versus APV + HEVp30 (20%) (P < 0.05) (Experiment II). These data indicated that APV reduced the efficacy of HEV vaccines in turkeys.

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalAvian Diseases
Volume46
Issue number2
StatePublished - 2002
Externally publishedYes

Fingerprint

Aviadenovirus
Metapneumovirus
Avian metapneumovirus
Enteritis
Siadenovirus
Vaccines
vaccines
Viruses
spleen
viruses
Pneumovirus Infections
immunosuppressive agents
Immunosuppressive Agents
Vaccination
vaccination

Keywords

  • Avian pneumovirus
  • Hemorrhagic enteritis virus
  • Turkey
  • Vaccination

ASJC Scopus subject areas

  • Immunology
  • Cancer Research
  • veterinary(all)

Cite this

Chary, P., Rautenschlein, S., & Sharma, J. M. (2002). Reduced efficacy of hemorrhagic enteritis virus vaccine in turkeys exposed to avian pneumovirus. Avian Diseases, 46(2), 353-359.

Reduced efficacy of hemorrhagic enteritis virus vaccine in turkeys exposed to avian pneumovirus. / Chary, Parag; Rautenschlein, Silke; Sharma, Jagdev M.

In: Avian Diseases, Vol. 46, No. 2, 2002, p. 353-359.

Research output: Contribution to journalArticle

Chary, P, Rautenschlein, S & Sharma, JM 2002, 'Reduced efficacy of hemorrhagic enteritis virus vaccine in turkeys exposed to avian pneumovirus', Avian Diseases, vol. 46, no. 2, pp. 353-359.
Chary, Parag ; Rautenschlein, Silke ; Sharma, Jagdev M. / Reduced efficacy of hemorrhagic enteritis virus vaccine in turkeys exposed to avian pneumovirus. In: Avian Diseases. 2002 ; Vol. 46, No. 2. pp. 353-359.
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