Recurrent and recent selective sweeps in the piRNA pathway

Alfred Simkin, Alex Wong, Yu Ping Poh, William E. Theurkauf, Jeffrey Jensen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Uncontrolled transposable element (TE) insertions and excisions can cause chromosome breaks and mutations with dramatic deleterious effects. The PIWI interacting RNA (piRNA) pathway functions as an adaptive TE silencing system during germline development. Several essential piRNA pathway proteins appear to be rapidly evolving, suggesting that TEs and the silencing machinery may be engaged in a classical "evolutionary arms race." Using a variety of molecular evolutionary and population genetic approaches, we find that the piRNA pathway genes rhino, krimper, and aubergine show patterns suggestive of extensive recurrent positive selection across Drosophila species. We speculate that selection on these proteins reflects crucial roles in silencing unfamiliar elements during vertical and horizontal transmission of TEs into naïve populations and species, respectively.

Original languageEnglish (US)
Pages (from-to)1081-1090
Number of pages10
JournalEvolution
Volume67
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Fingerprint

RNA
DNA Transposable Elements
transposons
Transcriptional Silencer Elements
chromosome breakage
Solanum melongena
horizontal transmission
arms race
vertical transmission
Chromosome Breakage
protein
Population Genetics
machinery
population genetics
Drosophila
Molecular Biology
chromosome
mutation
germ cells
Proteins

Keywords

  • Competition
  • Maternal effect
  • Molecular evolution
  • Parasitism
  • Polymorphism

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Ecology, Evolution, Behavior and Systematics
  • Genetics

Cite this

Simkin, A., Wong, A., Poh, Y. P., Theurkauf, W. E., & Jensen, J. (2013). Recurrent and recent selective sweeps in the piRNA pathway. Evolution, 67(4), 1081-1090. https://doi.org/10.1111/evo.12011

Recurrent and recent selective sweeps in the piRNA pathway. / Simkin, Alfred; Wong, Alex; Poh, Yu Ping; Theurkauf, William E.; Jensen, Jeffrey.

In: Evolution, Vol. 67, No. 4, 04.2013, p. 1081-1090.

Research output: Contribution to journalArticle

Simkin, A, Wong, A, Poh, YP, Theurkauf, WE & Jensen, J 2013, 'Recurrent and recent selective sweeps in the piRNA pathway', Evolution, vol. 67, no. 4, pp. 1081-1090. https://doi.org/10.1111/evo.12011
Simkin, Alfred ; Wong, Alex ; Poh, Yu Ping ; Theurkauf, William E. ; Jensen, Jeffrey. / Recurrent and recent selective sweeps in the piRNA pathway. In: Evolution. 2013 ; Vol. 67, No. 4. pp. 1081-1090.
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