Recurrence of primary sclerosing cholangitis after liver transplantation

Phunchai Charatcharoenwitthaya, Keith Lindor

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Primary sclerosing cholangitis (PSC) is a progressive inflammatory disease of unknown etiology affecting the bile ducts, leading to fibrosis and eventually cirrhosis in most patients. Liver transplantation is the only effective therapy for PSC patients with end-stage liver disease. As a result of increasing number of patients transplanted for PSC, recurrent PSC has become an important condition negatively affecting graft survival and perhaps patient survival. The difficulty of diagnosing recurrent PSC in the allograft is compounded several fold due to a variety of insults seen exclusively after transplantation which may result in biliary stricture. Identification of risk factors for recurrent PSC is important because it may potentially alter the management of patients after transplantation, and might offer clues to the pathogenesis of PSC. As for PSC in the native liver, treatment options are limited for recurrent PSC. For these important entities affecting PSC patients after liver transplantation, we review the current published data on epidemiology, diagnostic criteria, risk factors, graft and patient survival, and treatment of recurrent PSC.

Original languageEnglish (US)
Title of host publicationDisease Recurrence After Liver Transplantation: Natural History, Treatment and Survival
PublisherSpringer New York
Pages121-134
Number of pages14
ISBN (Print)9781493929474, 9781493929467
DOIs
StatePublished - Jan 1 2015

Keywords

  • Liver transplantation
  • Outcome
  • Primary sclerosing cholangitis
  • Recurrence
  • Risk factor
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Charatcharoenwitthaya, P., & Lindor, K. (2015). Recurrence of primary sclerosing cholangitis after liver transplantation. In Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival (pp. 121-134). Springer New York. https://doi.org/10.1007/978-1-4939-2947-4_8