Recording advances for neural prosthetics

R. A. Andersen, J. W. Burdick, S. Musallam, H. Scherberger, B. Pesaran, D. Meeker, B. D. Corneil, I. Fineman, Z. Nenadic, E. Branchaud, J. G. Cham, Bradley Greger, Y. C. Tai, M. M. Mojarradi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

19 Citations (Scopus)

Abstract

An important challenge for neural prosthetics research is to record from populations of neurons over long periods of time, ideally for the lifetime of the patient. Two new advances toward this goal are described, the use of local field potentials (LFPs) and autonomously positioned recording electrodes. LFPs are the composite extracellular potential field from several hundreds of neurons around the electrode tip. LFP recordings can be maintained for longer periods of time than single cell recordings. We find that similar information can be decoded from LFP and spike recordings, with better performance for state decodes with LFPs and, depending on the area, equivalent or slightly less than equivalent performance for signaling the direction of planned movements. Movable electrodes in microdrives can be adjusted in the tissue to optimize recordings, but their movements must be automated to be a practical benefit to patients. We have developed automation algorithms and a meso-scale autonomous electrode testbed, and demonstrated that this system can autonomously isolate and maintain the recorded signal quality of single cells in the cortex of awake, behaving monkeys. These two advances show promise for developing very long term recording for neural prosthetic applications.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages5352-5355
Number of pages4
Volume26 VII
StatePublished - 2004
Externally publishedYes
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Other

OtherConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
CountryUnited States
CitySan Francisco, CA
Period9/1/049/5/04

Fingerprint

Prosthetics
Electrodes
Neurons
Testbeds
Automation
Tissue
Composite materials

Keywords

  • LFP
  • Movable Electrodes
  • Neural Prosthetics

ASJC Scopus subject areas

  • Bioengineering

Cite this

Andersen, R. A., Burdick, J. W., Musallam, S., Scherberger, H., Pesaran, B., Meeker, D., ... Mojarradi, M. M. (2004). Recording advances for neural prosthetics. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 26 VII, pp. 5352-5355)

Recording advances for neural prosthetics. / Andersen, R. A.; Burdick, J. W.; Musallam, S.; Scherberger, H.; Pesaran, B.; Meeker, D.; Corneil, B. D.; Fineman, I.; Nenadic, Z.; Branchaud, E.; Cham, J. G.; Greger, Bradley; Tai, Y. C.; Mojarradi, M. M.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 26 VII 2004. p. 5352-5355.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Andersen, RA, Burdick, JW, Musallam, S, Scherberger, H, Pesaran, B, Meeker, D, Corneil, BD, Fineman, I, Nenadic, Z, Branchaud, E, Cham, JG, Greger, B, Tai, YC & Mojarradi, MM 2004, Recording advances for neural prosthetics. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 26 VII, pp. 5352-5355, Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004, San Francisco, CA, United States, 9/1/04.
Andersen RA, Burdick JW, Musallam S, Scherberger H, Pesaran B, Meeker D et al. Recording advances for neural prosthetics. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 26 VII. 2004. p. 5352-5355
Andersen, R. A. ; Burdick, J. W. ; Musallam, S. ; Scherberger, H. ; Pesaran, B. ; Meeker, D. ; Corneil, B. D. ; Fineman, I. ; Nenadic, Z. ; Branchaud, E. ; Cham, J. G. ; Greger, Bradley ; Tai, Y. C. ; Mojarradi, M. M. / Recording advances for neural prosthetics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 26 VII 2004. pp. 5352-5355
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