Recombination within and between the human insulin and β-globin gene loci

R. V. Lebo, A. Chakravarti, K. H. Buetow, M. C. Cheung, H. Cann, B. Cordell, H. Goodman

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Abstract

We detected a large number of polymorphic insulin restriction fragments in black Americans. These different size fragments were probably generated by unequal recombination on both sides of the human insulin gene. Population genetic analysis indicates that recombination occurred 33 times more frequently than expected to generate this large number of polymorphic fragments. Specific properties of the unique repeated 14- to 16-base-pair sequences 5' to the insulin gene suggest that this sequence would promote increased unequal recombination. Additional pedigree analysis showed that the recombination rate between the structural insulin and β-globin gene loci was 14% with strong evidence for linkage. Since both insulin and β-globin have been mapped to the short arm of human chromosome 11, this study establishes that the genetic map distance between these genes is 14.2 centimorgans.

Original languageEnglish (US)
Pages (from-to)4808-4812
Number of pages5
JournalUnknown Journal
Volume80
Issue number15 I
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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    Lebo, R. V., Chakravarti, A., Buetow, K. H., Cheung, M. C., Cann, H., Cordell, B., & Goodman, H. (1983). Recombination within and between the human insulin and β-globin gene loci. Unknown Journal, 80(15 I), 4808-4812. https://doi.org/10.1073/pnas.80.15.4808