Recombination shapes genome architecture in an organism from the archaeal domain

David J. Krause, Xavier Didelot, Hinsby Cadillo-Quiroz, Rachel J. Whitaker

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Variation in recombination rates across chromosomes has been shown to be a primary force shaping the architecture of genome divergence. In archaea, little is known about variation in recombination across the chromosome or how it shapes genome evolution. We identified significant variations in polymorphism occurring across the chromosomes of ten closely related sympatric strains of the thermoacidophilic archaeon Sulfolobus islandicus. Statistical analyses show that recombination varies across the genome and interacts with selection to define large genomic regions with reduced polymorphism, particularly in the regions surrounding the three origins of replication. Our findings demonstrate how recombination defines the mosaic of variation in this asexually reproducing microorganism and provide insight into the evolutionary origins of genome architecture in this organism from the Archaeal domain.

Original languageEnglish (US)
Pages (from-to)170-178
Number of pages9
JournalGenome biology and evolution
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Archaea
  • Recombination
  • Sulfolobus islandicus

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics

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