Recombination patterns in aphthoviruses mirror those found in other picornaviruses

Livio Heath, Eric Van Der Walt, Arvind Varsani, Darren P. Martin

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

Foot-and-mouth disease virus (FMDV) is thought to evolve largely through genetic drift driven by the inherently error-prone nature of its RNA polymerase. There is, however, increasing evidence that recombination is an important mechanism in the evolution of these and other related picornoviruses. Here, we use an extensive set of recombination detection methods to identify 86 unique potential recombination events among 125 publicly available FMDV complete genome sequences. The large number of events detected between members of different serotypes suggests that horizontal flow of sequences among the serotypes is relatively common and does not incur severe fitness costs. Interestingly, the distribution of recombination breakpoints was found to be largely nonrandom. Whereas there are clear breakpoint cold spots within the structural genes, two statistically significant hot spots precisely separate these from the nonstructural genes. Very similar breakpoint distributions were found for other picornovirus species in the genera Enterovirus and Teschovirus. Our results suggest that genome regions encoding the structural proteins of both FMDV and other picornaviruses are functionally interchangeable modules, supporting recent proposals that the structural and nonstructural coding regions of the picornaviruses are evolving largely independently of one another.

Original languageEnglish (US)
Pages (from-to)11827-11832
Number of pages6
JournalJournal of Virology
Volume80
Issue number23
DOIs
StatePublished - Dec 2006
Externally publishedYes

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Aphthovirus
Picornaviridae
Foot-and-mouth disease virus
Foot-and-Mouth Disease Virus
Genetic Recombination
Teschovirus
serotypes
Enterovirus
genome
structural genes
structural proteins
Genome
DNA-directed RNA polymerase
genetic drift
Genetic Drift
DNA-Directed RNA Polymerases
Genes
Costs and Cost Analysis
genes
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Recombination patterns in aphthoviruses mirror those found in other picornaviruses. / Heath, Livio; Van Der Walt, Eric; Varsani, Arvind; Martin, Darren P.

In: Journal of Virology, Vol. 80, No. 23, 12.2006, p. 11827-11832.

Research output: Contribution to journalArticle

Heath, Livio ; Van Der Walt, Eric ; Varsani, Arvind ; Martin, Darren P. / Recombination patterns in aphthoviruses mirror those found in other picornaviruses. In: Journal of Virology. 2006 ; Vol. 80, No. 23. pp. 11827-11832.
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