TY - CHAP
T1 - Recombinant Therapeutic Molecules Produced in Plants
AU - Chen, Qiang
N1 - Funding Information:
The author wish to thank Huafang Lai, Ming Yang, Haiyan Sun, Johnathan Hurtado, Adrian Esqueda, Collin Jugler, and other current and former members of the author's laboratory for their contribution to the research cited in this chapter. Research in the author's laboratory is supported in part by NIH-NIAID Grants U01 AI075549, 1R21AI101329, and R33AI101329 to Q.C.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018
Y1 - 2018
N2 - Research on the use of plants for production of protein-based therapeutics has increased tremendously since the initial experiments in the early 1990s. Plant-based expression systems offer several production advantages of low cost, rapidity, scalability, and a significantly lower chance of contamination with prion or mammalian viruses. In addition, the capability of plants in producing homogeneous N-glycans allows the development of novel therapeutics with superior efficacy and safety to their mammalian cell-produced counterparts. Various plant species have been used to develop and produce vaccines, antibodies, and pharmaceutical enzymes against a myriad of diseases by multiple expression technologies. While most of these plant-made therapeutics are in preclinical development, many have progressed into human clinical study phases and several have been approved by regulatory agencies. The current status and recent advancement of plant-based expression systems and key clinical products will be presented in this chapter. The remaining challenges and future directions for the field of plant-made therapeutics will be discussed.
AB - Research on the use of plants for production of protein-based therapeutics has increased tremendously since the initial experiments in the early 1990s. Plant-based expression systems offer several production advantages of low cost, rapidity, scalability, and a significantly lower chance of contamination with prion or mammalian viruses. In addition, the capability of plants in producing homogeneous N-glycans allows the development of novel therapeutics with superior efficacy and safety to their mammalian cell-produced counterparts. Various plant species have been used to develop and produce vaccines, antibodies, and pharmaceutical enzymes against a myriad of diseases by multiple expression technologies. While most of these plant-made therapeutics are in preclinical development, many have progressed into human clinical study phases and several have been approved by regulatory agencies. The current status and recent advancement of plant-based expression systems and key clinical products will be presented in this chapter. The remaining challenges and future directions for the field of plant-made therapeutics will be discussed.
KW - Flavivirus
KW - Monoclonal antibody
KW - Nicotiana benthamiana
KW - Plant expression system
KW - Plant-made biologics
KW - Plant-made pharmaceutical
KW - Therapeutic enzymes
KW - Transient expression
KW - Vaccine
KW - Virus-like particle
UR - http://www.scopus.com/inward/record.url?scp=85043366363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043366363&partnerID=8YFLogxK
U2 - 10.1016/bs.abr.2017.11.006
DO - 10.1016/bs.abr.2017.11.006
M3 - Chapter
AN - SCOPUS:85043366363
T3 - Advances in Botanical Research
SP - 207
EP - 244
BT - Advances in Botanical Research
A2 - Kuntz, Marcel
PB - Academic Press Inc
ER -