Recombinant Salmonella vectors in vaccine development.

R. Curtiss; S. M. Kelly; S. A. Tinge; C. O. Tacket; M. M. Levine; J. Srinivasan; M. Koopman

Recombinant Salmonella vectors in vaccine development.

R. Curtiss, S. M. Kelly, S. A. Tinge, C. O. Tacket, M. M. Levine, J. Srinivasan, M. Koopman

Research output: Contribution to journal › Review article › peer-review

Abstract

A diversity of means are available for the attenuation of Salmonella which can be used to immunize animals and humans orally to elicit mucosal, humoral and cellular immune responses. Avirulent Salmonellae can be genetically engineered to express foreign antigens and the recombinant avirulent Salmonellae are capable of stable, high-level expression of the foreign antigen in the orally immunized animal or human host. The resulting vaccines are safe, efficacious, and are easy and economical to use.

Original language	English (US)
Pages (from-to)	23-33
Number of pages	11
Journal	Developments in biological standardization
Volume	82
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

General Immunology and Microbiology
Drug Discovery
Public Health, Environmental and Occupational Health

Cite this

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title = "Recombinant Salmonella vectors in vaccine development.",

abstract = "A diversity of means are available for the attenuation of Salmonella which can be used to immunize animals and humans orally to elicit mucosal, humoral and cellular immune responses. Avirulent Salmonellae can be genetically engineered to express foreign antigens and the recombinant avirulent Salmonellae are capable of stable, high-level expression of the foreign antigen in the orally immunized animal or human host. The resulting vaccines are safe, efficacious, and are easy and economical to use.",

author = "R. Curtiss and Kelly, {S. M.} and Tinge, {S. A.} and Tacket, {C. O.} and Levine, {M. M.} and J. Srinivasan and M. Koopman",

year = "1994",

language = "English (US)",

volume = "82",

pages = "23--33",

journal = "Developments in biological standardization",

issn = "0301-5149",

publisher = "S. Karger AG",

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T1 - Recombinant Salmonella vectors in vaccine development.

AU - Curtiss, R.

AU - Kelly, S. M.

AU - Tinge, S. A.

AU - Tacket, C. O.

AU - Levine, M. M.

AU - Srinivasan, J.

AU - Koopman, M.

PY - 1994

Y1 - 1994

N2 - A diversity of means are available for the attenuation of Salmonella which can be used to immunize animals and humans orally to elicit mucosal, humoral and cellular immune responses. Avirulent Salmonellae can be genetically engineered to express foreign antigens and the recombinant avirulent Salmonellae are capable of stable, high-level expression of the foreign antigen in the orally immunized animal or human host. The resulting vaccines are safe, efficacious, and are easy and economical to use.

AB - A diversity of means are available for the attenuation of Salmonella which can be used to immunize animals and humans orally to elicit mucosal, humoral and cellular immune responses. Avirulent Salmonellae can be genetically engineered to express foreign antigens and the recombinant avirulent Salmonellae are capable of stable, high-level expression of the foreign antigen in the orally immunized animal or human host. The resulting vaccines are safe, efficacious, and are easy and economical to use.

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M3 - Review article

C2 - 7958478

AN - SCOPUS:0028190147

SN - 0301-5149

VL - 82

SP - 23

EP - 33

JO - Developments in biological standardization

JF - Developments in biological standardization

ER -

Recombinant Salmonella vectors in vaccine development.

Abstract

ASJC Scopus subject areas

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