Recombinant Salmonella vectors in vaccine development.

R. Curtiss, S. M. Kelly, S. A. Tinge, C. O. Tacket, M. M. Levine, J. Srinivasan, M. Koopman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A diversity of means are available for the attenuation of Salmonella which can be used to immunize animals and humans orally to elicit mucosal, humoral and cellular immune responses. Avirulent Salmonellae can be genetically engineered to express foreign antigens and the recombinant avirulent Salmonellae are capable of stable, high-level expression of the foreign antigen in the orally immunized animal or human host. The resulting vaccines are safe, efficacious, and are easy and economical to use.

Original languageEnglish (US)
Pages (from-to)23-33
Number of pages11
JournalDevelopments in Biological Standardization
Volume82
StatePublished - 1994
Externally publishedYes

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Salmonella
Vaccines
Antigens
Mucosal Immunity
Humoral Immunity
Cellular Immunity

ASJC Scopus subject areas

  • Biotechnology

Cite this

Curtiss, R., Kelly, S. M., Tinge, S. A., Tacket, C. O., Levine, M. M., Srinivasan, J., & Koopman, M. (1994). Recombinant Salmonella vectors in vaccine development. Developments in Biological Standardization, 82, 23-33.

Recombinant Salmonella vectors in vaccine development. / Curtiss, R.; Kelly, S. M.; Tinge, S. A.; Tacket, C. O.; Levine, M. M.; Srinivasan, J.; Koopman, M.

In: Developments in Biological Standardization, Vol. 82, 1994, p. 23-33.

Research output: Contribution to journalArticle

Curtiss, R, Kelly, SM, Tinge, SA, Tacket, CO, Levine, MM, Srinivasan, J & Koopman, M 1994, 'Recombinant Salmonella vectors in vaccine development.', Developments in Biological Standardization, vol. 82, pp. 23-33.
Curtiss R, Kelly SM, Tinge SA, Tacket CO, Levine MM, Srinivasan J et al. Recombinant Salmonella vectors in vaccine development. Developments in Biological Standardization. 1994;82:23-33.
Curtiss, R. ; Kelly, S. M. ; Tinge, S. A. ; Tacket, C. O. ; Levine, M. M. ; Srinivasan, J. ; Koopman, M. / Recombinant Salmonella vectors in vaccine development. In: Developments in Biological Standardization. 1994 ; Vol. 82. pp. 23-33.
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