Recombinant immune complexes as versatile and potent vaccines

Research output: Contribution to journalComment/debate

5 Scopus citations

Abstract

Immune complexes (IC) used as vaccines have the potential to enhance both antibody and cell-mediated immune responses over those obtained with antigen alone. However, difficulty of manufacture represents a significant hurdle to the widespread use of IC as vaccines. Recombinant IC (RIC) and their expression in plants enable manufacturing by the coordinate expression of immunoglobulin and antigen as a fusion protein. The use of a modular RIC system facilitates insertion of antigen genes and provides a broadly applicable platform that can be adapted for a wide variety of antigens.

Original languageEnglish (US)
Pages (from-to)988-989
Number of pages2
JournalHuman Vaccines and Immunotherapeutics
Volume12
Issue number4
DOIs
StatePublished - Apr 2 2016

Keywords

  • antibody fusion
  • immune complex
  • recombinant plant
  • transient expression
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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