Recombinant immune complexes as versatile and potent vaccines

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Immune complexes (IC) used as vaccines have the potential to enhance both antibody and cell-mediated immune responses over those obtained with antigen alone. However, difficulty of manufacture represents a significant hurdle to the widespread use of IC as vaccines. Recombinant IC (RIC) and their expression in plants enable manufacturing by the coordinate expression of immunoglobulin and antigen as a fusion protein. The use of a modular RIC system facilitates insertion of antigen genes and provides a broadly applicable platform that can be adapted for a wide variety of antigens.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalHuman Vaccines and Immunotherapeutics
DOIs
StateAccepted/In press - Mar 16 2016

Fingerprint

Antigen-Antibody Complex
Vaccines
Antigens
Insertional Mutagenesis
Immunoglobulins
Antibodies
Proteins

Keywords

  • antibody fusion
  • immune complex
  • recombinant plant
  • transient expression
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Recombinant immune complexes as versatile and potent vaccines . / Mason, Hugh.

In: Human Vaccines and Immunotherapeutics, 16.03.2016, p. 1-2.

Research output: Contribution to journalArticle

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