Recombinant immune complexes as versatile and potent vaccines

Hugh Mason

doi:10.1080/21645515.2015.1116655

Recombinant immune complexes as versatile and potent vaccines

Hugh Mason

Research output: Contribution to journal › Comment/debate › peer-review

11 Scopus citations

Abstract

Immune complexes (IC) used as vaccines have the potential to enhance both antibody and cell-mediated immune responses over those obtained with antigen alone. However, difficulty of manufacture represents a significant hurdle to the widespread use of IC as vaccines. Recombinant IC (RIC) and their expression in plants enable manufacturing by the coordinate expression of immunoglobulin and antigen as a fusion protein. The use of a modular RIC system facilitates insertion of antigen genes and provides a broadly applicable platform that can be adapted for a wide variety of antigens.

Original language	English (US)
Pages (from-to)	988-989
Number of pages	2
Journal	Human Vaccines and Immunotherapeutics
Volume	12
Issue number	4
DOIs	https://doi.org/10.1080/21645515.2015.1116655
State	Published - Apr 2 2016

Keywords

antibody fusion
immune complex
recombinant plant
transient expression
vaccine

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

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10.1080/21645515.2015.1116655

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abstract = "Immune complexes (IC) used as vaccines have the potential to enhance both antibody and cell-mediated immune responses over those obtained with antigen alone. However, difficulty of manufacture represents a significant hurdle to the widespread use of IC as vaccines. Recombinant IC (RIC) and their expression in plants enable manufacturing by the coordinate expression of immunoglobulin and antigen as a fusion protein. The use of a modular RIC system facilitates insertion of antigen genes and provides a broadly applicable platform that can be adapted for a wide variety of antigens.",

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AB - Immune complexes (IC) used as vaccines have the potential to enhance both antibody and cell-mediated immune responses over those obtained with antigen alone. However, difficulty of manufacture represents a significant hurdle to the widespread use of IC as vaccines. Recombinant IC (RIC) and their expression in plants enable manufacturing by the coordinate expression of immunoglobulin and antigen as a fusion protein. The use of a modular RIC system facilitates insertion of antigen genes and provides a broadly applicable platform that can be adapted for a wide variety of antigens.

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KW - recombinant plant

KW - transient expression

KW - vaccine

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Recombinant immune complexes as versatile and potent vaccines

Abstract

Keywords

ASJC Scopus subject areas

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