Abstract

Single molecules in a tunnel junction can now be interrogated reliably using chemically functionalized electrodes. Monitoring stochastic bonding fluctuations between a ligand bound to one electrode and its target bound to a second electrode ('tethered molecule-pair' configuration) gives insight into the nature of the intermolecular bonding at a single molecule-pair level, and defines the requirements for reproducible tunneling data. Simulations show that there is an instability in the tunnel gap at large currents, and this results in a multiplicity of contacts with a corresponding spread in the measured currents. At small currents (i.e.large gaps) the gap is stable, and functionalizing a pair of electrodes with recognition reagents (the 'free-analyte' configuration) can generate a distinct tunneling signal when an analyte molecule is trapped in the gap. This opens up a new interface between chemistry and electronics with immediate implications for rapid sequencing of single DNA molecules.

Original languageEnglish (US)
Article number262001
JournalNanotechnology
Volume21
Issue number26
DOIs
StatePublished - 2010

Fingerprint

Molecules
Electrodes
Tunnel junctions
Tunnels
DNA
Electronic equipment
Ligands
Monitoring

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Science(all)

Cite this

Lindsay, S., He, J., Sankey, O., Hapala, P., Jelinek, P., Zhang, P., ... Huang, S. (2010). Recognition tunneling. Nanotechnology, 21(26), [262001]. https://doi.org/10.1088/0957-4484/21/26/262001

Recognition tunneling. / Lindsay, Stuart; He, Jin; Sankey, Otto; Hapala, Prokop; Jelinek, Pavel; Zhang, Peiming; Chang, Shuai; Huang, Shuo.

In: Nanotechnology, Vol. 21, No. 26, 262001, 2010.

Research output: Contribution to journalArticle

Lindsay, S, He, J, Sankey, O, Hapala, P, Jelinek, P, Zhang, P, Chang, S & Huang, S 2010, 'Recognition tunneling', Nanotechnology, vol. 21, no. 26, 262001. https://doi.org/10.1088/0957-4484/21/26/262001
Lindsay S, He J, Sankey O, Hapala P, Jelinek P, Zhang P et al. Recognition tunneling. Nanotechnology. 2010;21(26). 262001. https://doi.org/10.1088/0957-4484/21/26/262001
Lindsay, Stuart ; He, Jin ; Sankey, Otto ; Hapala, Prokop ; Jelinek, Pavel ; Zhang, Peiming ; Chang, Shuai ; Huang, Shuo. / Recognition tunneling. In: Nanotechnology. 2010 ; Vol. 21, No. 26.
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