TY - JOUR
T1 - Recent studies of ribonuclease P
AU - Altman, S.
AU - Kirsebom, L.
AU - Talbot, S.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - RNase P is an essential enzyme that is required for the biosynthesis of tRNA. It is composed of RNA and protein subunits. The RNA subunit of the enzyme derived from eubacterial sources can carry out the catalytic function by itself in vitro. Current studies of RNase P focus on structure-function relationships with respect to interactions of the RNA subunit with its substrates and with respect to the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.
AB - RNase P is an essential enzyme that is required for the biosynthesis of tRNA. It is composed of RNA and protein subunits. The RNA subunit of the enzyme derived from eubacterial sources can carry out the catalytic function by itself in vitro. Current studies of RNase P focus on structure-function relationships with respect to interactions of the RNA subunit with its substrates and with respect to the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.
KW - RNA-protein interactions
KW - catalytic RNA
KW - phylogenetic comparisons
KW - tRNA biosynthesis
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U2 - 10.1096/fasebj.7.1.7916700
DO - 10.1096/fasebj.7.1.7916700
M3 - Review article
C2 - 7916700
AN - SCOPUS:0027389799
VL - 7
SP - 7
EP - 14
JO - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
JF - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
SN - 0892-6638
IS - 1
ER -