Abstract
RNase P is an essential enzyme that is required for the biosynthesis of tRNA. It is composed of RNA and protein subunits. The RNA subunit of the enzyme derived from eubacterial sources can carry out the catalytic function by itself in vitro. Current studies of RNase P focus on structure-function relationships with respect to interactions of the RNA subunit with its substrates and with respect to the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7-14 |
| Number of pages | 8 |
| Journal | FASEB Journal |
| Volume | 7 |
| Issue number | 1 |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- catalytic RNA
- phylogenetic comparisons
- RNA-protein interactions
- tRNA biosynthesis
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
Cite this
Recent studies of ribonuclease P. / Altman, Sidney; Kirsebom, L.; Talbot, S.
In: FASEB Journal, Vol. 7, No. 1, 1993, p. 7-14.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Recent studies of ribonuclease P
AU - Altman, Sidney
AU - Kirsebom, L.
AU - Talbot, S.
PY - 1993
Y1 - 1993
N2 - RNase P is an essential enzyme that is required for the biosynthesis of tRNA. It is composed of RNA and protein subunits. The RNA subunit of the enzyme derived from eubacterial sources can carry out the catalytic function by itself in vitro. Current studies of RNase P focus on structure-function relationships with respect to interactions of the RNA subunit with its substrates and with respect to the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.
AB - RNase P is an essential enzyme that is required for the biosynthesis of tRNA. It is composed of RNA and protein subunits. The RNA subunit of the enzyme derived from eubacterial sources can carry out the catalytic function by itself in vitro. Current studies of RNase P focus on structure-function relationships with respect to interactions of the RNA subunit with its substrates and with respect to the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.
KW - catalytic RNA
KW - phylogenetic comparisons
KW - RNA-protein interactions
KW - tRNA biosynthesis
UR - http://www.scopus.com/inward/record.url?scp=0027389799&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027389799&partnerID=8YFLogxK
M3 - Review article
C2 - 7916700
AN - SCOPUS:0027389799
VL - 7
SP - 7
EP - 14
JO - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
JF - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
SN - 0892-6638
IS - 1
ER -