Recent studies of ribonuclease P

Sidney Altman, L. Kirsebom, S. Talbot

Research output: Contribution to journalReview article

134 Citations (Scopus)

Abstract

RNase P is an essential enzyme that is required for the biosynthesis of tRNA. It is composed of RNA and protein subunits. The RNA subunit of the enzyme derived from eubacterial sources can carry out the catalytic function by itself in vitro. Current studies of RNase P focus on structure-function relationships with respect to interactions of the RNA subunit with its substrates and with respect to the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalFASEB Journal
Volume7
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

Ribonuclease P
ribonucleases
RNA
protein subunits
Biosynthesis
Protein Subunits
Substrates
structure-activity relationships
Enzymes
Transfer RNA
Kinetic parameters
biosynthesis
kinetics
enzymes
Proteins
proteins

Keywords

  • catalytic RNA
  • phylogenetic comparisons
  • RNA-protein interactions
  • tRNA biosynthesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Altman, S., Kirsebom, L., & Talbot, S. (1993). Recent studies of ribonuclease P. FASEB Journal, 7(1), 7-14.

Recent studies of ribonuclease P. / Altman, Sidney; Kirsebom, L.; Talbot, S.

In: FASEB Journal, Vol. 7, No. 1, 1993, p. 7-14.

Research output: Contribution to journalReview article

Altman, S, Kirsebom, L & Talbot, S 1993, 'Recent studies of ribonuclease P', FASEB Journal, vol. 7, no. 1, pp. 7-14.
Altman S, Kirsebom L, Talbot S. Recent studies of ribonuclease P. FASEB Journal. 1993;7(1):7-14.
Altman, Sidney ; Kirsebom, L. ; Talbot, S. / Recent studies of ribonuclease P. In: FASEB Journal. 1993 ; Vol. 7, No. 1. pp. 7-14.
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