Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites

Kazuyuki Tanabe, Ananias Escalante, Naoko Sakihama, Masanori Honda, Nobuko Arisue, Toshihiro Horii, Richard Culleton, Toshiyuki Hayakawa, Tetsuo Hashimoto, Shirley Longacre, Sisira Pathirana, Shiroma Handunnetti, Hirohisa Kishino

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The Plasmodium MSP-1 is a promising malaria vaccine candidate. However, the highly polymorphic nature of the MSP-1 gene (msp1) presents a potential obstacle for effective vaccine development. To investigate the evolutionary history of msp1 polymorphism in P. vivax, we construct phylogenetic trees of msp1 from P. vivax and related monkey malaria parasite species. All P. vivax msp1 alleles cluster in the P. vivax lineage and are not distributed among other species. Similarly, all P. cynomolgi msp1 alleles cluster in the P. cynomolgi lineage. This suggests that, in contrast to presumed ancient origin of P. falciparum msp1 polymorphism, the origin of P. vivax msp1 polymorphism is relatively recent. We observed positive selection in the P. vivax lineage but not in P. cynomolgi. Also, positive selection acts on different regions of msp1 in P. vivax and P. falciparum. This study shows that the evolutionary history of msp1 differs greatly among parasite lineages.

Original languageEnglish (US)
Pages (from-to)74-79
Number of pages6
JournalMolecular and Biochemical Parasitology
Volume156
Issue number1
DOIs
StatePublished - Nov 2007

Fingerprint

Merozoite Surface Protein 1
Plasmodium vivax
Malaria
Parasites
Genes
Multigene Family
History
Alleles
Malaria Vaccines
Plasmodium
Haplorhini
Vaccines

Keywords

  • Evolution
  • Malaria
  • msp1
  • Plasmodium cynomolgi
  • Plasmodium vivax
  • Polymorphism

ASJC Scopus subject areas

  • Molecular Biology
  • Parasitology

Cite this

Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites. / Tanabe, Kazuyuki; Escalante, Ananias; Sakihama, Naoko; Honda, Masanori; Arisue, Nobuko; Horii, Toshihiro; Culleton, Richard; Hayakawa, Toshiyuki; Hashimoto, Tetsuo; Longacre, Shirley; Pathirana, Sisira; Handunnetti, Shiroma; Kishino, Hirohisa.

In: Molecular and Biochemical Parasitology, Vol. 156, No. 1, 11.2007, p. 74-79.

Research output: Contribution to journalArticle

Tanabe, K, Escalante, A, Sakihama, N, Honda, M, Arisue, N, Horii, T, Culleton, R, Hayakawa, T, Hashimoto, T, Longacre, S, Pathirana, S, Handunnetti, S & Kishino, H 2007, 'Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites', Molecular and Biochemical Parasitology, vol. 156, no. 1, pp. 74-79. https://doi.org/10.1016/j.molbiopara.2007.07.002
Tanabe, Kazuyuki ; Escalante, Ananias ; Sakihama, Naoko ; Honda, Masanori ; Arisue, Nobuko ; Horii, Toshihiro ; Culleton, Richard ; Hayakawa, Toshiyuki ; Hashimoto, Tetsuo ; Longacre, Shirley ; Pathirana, Sisira ; Handunnetti, Shiroma ; Kishino, Hirohisa. / Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites. In: Molecular and Biochemical Parasitology. 2007 ; Vol. 156, No. 1. pp. 74-79.
@article{55f5e1fa8fc0411fafc74a4c53548557,
title = "Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites",
abstract = "The Plasmodium MSP-1 is a promising malaria vaccine candidate. However, the highly polymorphic nature of the MSP-1 gene (msp1) presents a potential obstacle for effective vaccine development. To investigate the evolutionary history of msp1 polymorphism in P. vivax, we construct phylogenetic trees of msp1 from P. vivax and related monkey malaria parasite species. All P. vivax msp1 alleles cluster in the P. vivax lineage and are not distributed among other species. Similarly, all P. cynomolgi msp1 alleles cluster in the P. cynomolgi lineage. This suggests that, in contrast to presumed ancient origin of P. falciparum msp1 polymorphism, the origin of P. vivax msp1 polymorphism is relatively recent. We observed positive selection in the P. vivax lineage but not in P. cynomolgi. Also, positive selection acts on different regions of msp1 in P. vivax and P. falciparum. This study shows that the evolutionary history of msp1 differs greatly among parasite lineages.",
keywords = "Evolution, Malaria, msp1, Plasmodium cynomolgi, Plasmodium vivax, Polymorphism",
author = "Kazuyuki Tanabe and Ananias Escalante and Naoko Sakihama and Masanori Honda and Nobuko Arisue and Toshihiro Horii and Richard Culleton and Toshiyuki Hayakawa and Tetsuo Hashimoto and Shirley Longacre and Sisira Pathirana and Shiroma Handunnetti and Hirohisa Kishino",
year = "2007",
month = "11",
doi = "10.1016/j.molbiopara.2007.07.002",
language = "English (US)",
volume = "156",
pages = "74--79",
journal = "Molecular and Biochemical Parasitology",
issn = "0166-6851",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites

AU - Tanabe, Kazuyuki

AU - Escalante, Ananias

AU - Sakihama, Naoko

AU - Honda, Masanori

AU - Arisue, Nobuko

AU - Horii, Toshihiro

AU - Culleton, Richard

AU - Hayakawa, Toshiyuki

AU - Hashimoto, Tetsuo

AU - Longacre, Shirley

AU - Pathirana, Sisira

AU - Handunnetti, Shiroma

AU - Kishino, Hirohisa

PY - 2007/11

Y1 - 2007/11

N2 - The Plasmodium MSP-1 is a promising malaria vaccine candidate. However, the highly polymorphic nature of the MSP-1 gene (msp1) presents a potential obstacle for effective vaccine development. To investigate the evolutionary history of msp1 polymorphism in P. vivax, we construct phylogenetic trees of msp1 from P. vivax and related monkey malaria parasite species. All P. vivax msp1 alleles cluster in the P. vivax lineage and are not distributed among other species. Similarly, all P. cynomolgi msp1 alleles cluster in the P. cynomolgi lineage. This suggests that, in contrast to presumed ancient origin of P. falciparum msp1 polymorphism, the origin of P. vivax msp1 polymorphism is relatively recent. We observed positive selection in the P. vivax lineage but not in P. cynomolgi. Also, positive selection acts on different regions of msp1 in P. vivax and P. falciparum. This study shows that the evolutionary history of msp1 differs greatly among parasite lineages.

AB - The Plasmodium MSP-1 is a promising malaria vaccine candidate. However, the highly polymorphic nature of the MSP-1 gene (msp1) presents a potential obstacle for effective vaccine development. To investigate the evolutionary history of msp1 polymorphism in P. vivax, we construct phylogenetic trees of msp1 from P. vivax and related monkey malaria parasite species. All P. vivax msp1 alleles cluster in the P. vivax lineage and are not distributed among other species. Similarly, all P. cynomolgi msp1 alleles cluster in the P. cynomolgi lineage. This suggests that, in contrast to presumed ancient origin of P. falciparum msp1 polymorphism, the origin of P. vivax msp1 polymorphism is relatively recent. We observed positive selection in the P. vivax lineage but not in P. cynomolgi. Also, positive selection acts on different regions of msp1 in P. vivax and P. falciparum. This study shows that the evolutionary history of msp1 differs greatly among parasite lineages.

KW - Evolution

KW - Malaria

KW - msp1

KW - Plasmodium cynomolgi

KW - Plasmodium vivax

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=34548362092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548362092&partnerID=8YFLogxK

U2 - 10.1016/j.molbiopara.2007.07.002

DO - 10.1016/j.molbiopara.2007.07.002

M3 - Article

C2 - 17706800

AN - SCOPUS:34548362092

VL - 156

SP - 74

EP - 79

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

SN - 0166-6851

IS - 1

ER -