TY - JOUR
T1 - Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites
AU - Tanabe, Kazuyuki
AU - Escalante, Ananias
AU - Sakihama, Naoko
AU - Honda, Masanori
AU - Arisue, Nobuko
AU - Horii, Toshihiro
AU - Culleton, Richard
AU - Hayakawa, Toshiyuki
AU - Hashimoto, Tetsuo
AU - Longacre, Shirley
AU - Pathirana, Sisira
AU - Handunnetti, Shiroma
AU - Kishino, Hirohisa
N1 - Funding Information:
We thank D. Conway for comments, and C. Amaratunga and W. Wijayalath for preparing Toque monkey parasite DNA samples. This work was supported by MEXT (18073013) and JSPS (18390131, 17-05495, 18GS03140013).
PY - 2007/11
Y1 - 2007/11
N2 - The Plasmodium MSP-1 is a promising malaria vaccine candidate. However, the highly polymorphic nature of the MSP-1 gene (msp1) presents a potential obstacle for effective vaccine development. To investigate the evolutionary history of msp1 polymorphism in P. vivax, we construct phylogenetic trees of msp1 from P. vivax and related monkey malaria parasite species. All P. vivax msp1 alleles cluster in the P. vivax lineage and are not distributed among other species. Similarly, all P. cynomolgi msp1 alleles cluster in the P. cynomolgi lineage. This suggests that, in contrast to presumed ancient origin of P. falciparum msp1 polymorphism, the origin of P. vivax msp1 polymorphism is relatively recent. We observed positive selection in the P. vivax lineage but not in P. cynomolgi. Also, positive selection acts on different regions of msp1 in P. vivax and P. falciparum. This study shows that the evolutionary history of msp1 differs greatly among parasite lineages.
AB - The Plasmodium MSP-1 is a promising malaria vaccine candidate. However, the highly polymorphic nature of the MSP-1 gene (msp1) presents a potential obstacle for effective vaccine development. To investigate the evolutionary history of msp1 polymorphism in P. vivax, we construct phylogenetic trees of msp1 from P. vivax and related monkey malaria parasite species. All P. vivax msp1 alleles cluster in the P. vivax lineage and are not distributed among other species. Similarly, all P. cynomolgi msp1 alleles cluster in the P. cynomolgi lineage. This suggests that, in contrast to presumed ancient origin of P. falciparum msp1 polymorphism, the origin of P. vivax msp1 polymorphism is relatively recent. We observed positive selection in the P. vivax lineage but not in P. cynomolgi. Also, positive selection acts on different regions of msp1 in P. vivax and P. falciparum. This study shows that the evolutionary history of msp1 differs greatly among parasite lineages.
KW - Evolution
KW - Malaria
KW - Plasmodium cynomolgi
KW - Plasmodium vivax
KW - Polymorphism
KW - msp1
UR - http://www.scopus.com/inward/record.url?scp=34548362092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548362092&partnerID=8YFLogxK
U2 - 10.1016/j.molbiopara.2007.07.002
DO - 10.1016/j.molbiopara.2007.07.002
M3 - Article
C2 - 17706800
AN - SCOPUS:34548362092
SN - 0166-6851
VL - 156
SP - 74
EP - 79
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
IS - 1
ER -