Recent duplication and positive selection of the GAGE gene family

Yang Liu, Qiyun Zhu, Naishuo Zhu

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We report that the GAGE gene family of human Cancer/testis antigen (CTA) genes is likely to be in an early stage of its evolution. Members of this gene family are tandemly arranged on the X chromosome only in human, chimpanzee and macaque genomes and share a very high similarity. Phylogenetic trees show that the GAGE gene family began to duplicate after the split of human and chimpanzee. The estimated ages of the duplication events range from 4 million years ago to the present. The Ka/Ks values between the duplicates are significantly greater than 1, indicating that the mutation rate is higher in coding regions than non-coding regions of the genes, which suggests that the GAGE gene family is under positive selection. These findings indicate that the GAGE gene family may be a newly formed gene family undergoing rapid functional evolution.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
Issue number1
StatePublished - May 2008
Externally publishedYes


  • Duplication
  • GAGE
  • Positive selection
  • Primate

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics
  • Plant Science
  • Insect Science


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