Recent developments in kidney transplantation - A critical assessment

K. L. Womer, B. Kaplan

    Research output: Contribution to journalShort surveypeer-review

    59 Scopus citations

    Abstract

    Rapid advances have been made in decreasing acute rejection rates and improving short-term graft survival in kidney transplant recipients. Whether these advances ultimately will lead to a commensurate improvement in long-term survival is not yet known. In recent years, greater attention has been placed on defining the precise etiology of graft loss, determining how far and with what agents we can minimize immunosuppression, and delineating the nature of both T-cell-mediated as well as antibody-mediated rejection. In addition, with the growing disparity of available organs and patients in need of a transplant, greater attention has been placed on optimizing allocation. In this minireview, we will focus on developments over the last couple of years, paying particular attention to insights, studies and observations that may attempt to elucidate some of these open questions.

    Original languageEnglish (US)
    Pages (from-to)1265-1271
    Number of pages7
    JournalAmerican Journal of Transplantation
    Volume9
    Issue number6
    DOIs
    StatePublished - Jun 2009

    Keywords

    • BK virus
    • Blood type incompatible transplantation
    • Immunosuppression withdrawal
    • Kidney transplantation
    • Rejection
    • Transplant tolerance

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Transplantation
    • Pharmacology (medical)

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